Results 51 to 60 of about 3,156,760 (295)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
On solving fully fuzzy multi-criteria De Novo programming via fuzzy goal programming approach [PDF]
Journal of Applied Research on Industrial Engineering, 2018 In this paper, a Multi-Criteria De Novo Linear Programming (F- MDNLP) problem has been developed under consideration of the ambiguity of parameters. These fuzzy parameters are characterized by fuzzy numbers.
Hamiden Khalifa
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Optimisasi Portofolio Saham Perbankan dengan Pendekatan Lexicographic Goal Programming
, 2014 Investment is a fund placement into productive assets or companies with hope of getting capital growth or profit in a certain period. When investing, an investor should make a portfolio, a combination of several stocks.
Panjaitan, Jentina Rotua
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
An optimization model for production planning in the drying sector of an industrial laundry
Acta Scientiarum: Technology, 2017 In this work, an optimization model was developed for production planning in the drying sector of a real industrial laundry. Goal programming was used in order to minimize energy and labor costs, and to use of the full capacity of each piece of equipment,
Eduardo Alves Oliveira +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
A Quadratic Regression Approach Using Mathematical Goal Programming [PDF]
Maǧallaẗ Al-Buḥūṯ Al-TiǧāriyyaẗGoal programming is a method commonly used to solve multi-criteria decision problems in different areas, such as manufacturing, production planning, marketing, supply chains, healthcare, management science, environment and energy.
Doaa Hassan +3 more
doaj +1 more source