Results 181 to 190 of about 1,137,797 (365)

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

open access: yesAdvanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt   +2 more
wiley   +1 more source

Mechanically Tunable Bone Scaffolds: In Vivo Hardening of 3D‐Printed Calcium Phosphate/Polycaprolactone Inks

open access: yesAdvanced Functional Materials, EarlyView.
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz   +7 more
wiley   +1 more source

Bicontinuous Microarchitected Scaffolds Provide Topographic Cues That Govern Neuronal Behavior and Maturation

open access: yesAdvanced Functional Materials, EarlyView.
A scalable biomimetic platform transforms bioinert poly(ethylene glycol) diacrylate into neuroinstructive matrices via integrating solvent transfer‐induced phase separation, microfluidics, and 3D bioprinting. Bicontinuous, hyperbolically curved microporous networks embedded within a fibrous construct elicit rapid adhesion, robust proliferation, and ...
Prince D. Okoro   +8 more
wiley   +1 more source

Polymer‐Incorporated Mechanically Compliant Carbon Nanotube Microelectrode Arrays for Multichannel Neural Signal Recording

open access: yesAdvanced Functional Materials, EarlyView.
This work presents a soft microelectrode array based on vertically aligned carbon nanotube (CNT) forests, combining high conductivity with mechanical softness. A densification process and air‐pressure‐assisted flexibilization improve structural integrity, ensuring stable insertion and reduced inflammation.
Hyeonhee Roh   +8 more
wiley   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

open access: yesAdvanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen   +30 more
wiley   +1 more source

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