Results 191 to 200 of about 69,761 (267)

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Pathological Features and Genotyping of <i>Mycobacterium avium sub</i> spp. <i>paratuberculosis</i> (MAP) in Small Ruminants in Saudi Arabia. [PDF]

Pathogens
Albaqshi H, Hamouda M, Aljasem Y, Karam R, Al Hizab FA.   +4 more
europepmc   +1 more source

Retinal Degeneration in a Goat

Journal of the American Veterinary Medical Association, 1980
openaire   +3 more sources

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Rumen Mycobiome Thiamine Metabolism Contributes to Subacute Rumen Acidosis Tolerance in Goats Through Enhancing Epithelial Cell Proliferation via IGFBP2/IGF1 Axis Activation. [PDF]

Exploration (Beijing)
Xu J, Chen X, Ma Y, Ren J, Xu G, Zhang P, Jia W, Deng Q, Xiao Y, Yao J, Wu S.   +10 more
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Prevalence and associated bacteria of mastitis in goats in northeastern Ethiopia. [PDF]

BMC Vet Res
Tibebu A, Tamrat H, Tsehayneh B, Teshome Y.   +3 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Prevalence and Antimicrobial Susceptibility of <i>Escherichia coli</i> O157:H7 Isolated From Slaughtered Sheep, Goats, and the Surrounding Environment at Haramaya Municipal Abattoir, Eastern Ethiopia. [PDF]

Vet Med Int
Asmelash A, Abrahim Y, Syoum A, Gebrezgabiher G.   +3 more
europepmc   +1 more source

Seroprevalence of Peste des Petits Ruminants (PPR) and associated risk factors in selected sub-counties of Lyantonde district, South Western Uganda. [PDF]

BMC Vet Res
Musiime E, Bwambale K, Babirye P, Lumu P, Mutebi F, Mugizi DR, Onyuth H.   +6 more
europepmc   +1 more source