Results 101 to 110 of about 4,483,397 (290)

Immunoreactivity against goblet cells in patients with inflammatory bowel disease

, 2008
BACKGROUND: A number of autoantibodies have been reported in inflammatory bowel disease (IBD). The aim of this study was to investigate to what extent sera from patients with IBD contain autoantibodies directed against normal human gastrointestinal ...
Rorsman, Fredrik, Grimelius, Lars, Ardesjö, Brita, Brita Ardesjö, Olov Ekwall, Lars Lööf, Lööf, Lars, Ekwall, Olov,, Fredrik Rorsman, Kämpe, Olle, Portela-Gomes, Guida M, Gerdin, Eva, Lars Grimelius, Guida M. Portela-Gomes, Eva Gerdin, Olle Kämpe   +15 more
core   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Age-related decline in goblet cell numbers and mucin content of the human colon: Implications for lower bowel functions in the elderly

Experimental and Molecular Pathology
Background & aims: Older people experience a greater incidence of lower bowel disorders, including constipation. Causes can include factors associated with growing older, such as use of medications or disease, but compounded by degenerative changes ...
Nicholas Baidoo, Gareth J. Sanger
doaj   +1 more source

Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells.

PLoS ONE, 2012
BackgroundMammalian Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that is required for the production of intestinal mucus and Paneth and goblet cell homeostasis. However, whether increased endoplasmic reticulum (ER) stress occurs in Agr2(-/-
Yi-Chung Chen, Yu-Fen Lu, I-Chen Li, Sheng-Ping L Hwang   +3 more
doaj   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Light microscopic study on the absorptive cells and goblet cells in the intestine of adult common carp Cyprinus carpio

The Iraqi Journal of Veterinary Medicine, 2019
The purpose of this study was to describe of some histological structures and histochemical features of the absorptive cells and goblet cells in intestine of common carp. In this study, Fifteen adult male common carp were catching alive from the AL-Forat
Khalid Hadi Kadhim
doaj   +1 more source

LOCALIZATION OF TLR2 IN INTESTINAL GOBLET CELLS OF EPTATRETUS CIRRATHUS

, 2022
Eptatretus cirrhatus (New Zealand hagfish) is a member of the Myxinidae family, together with the lampreys form the group of primitive jawless fishes (Agnatha).
Alessio Alesci, Emmanuel Messina, Roberta D’Angelo, Patrizia Lo Cascio., Angelica Mangano, Ddario Di Fresco, Maria Costanzo   +6 more
core  

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Role of epidermal growth factor receptor activation in regulating mucin synthesis

Respiratory Research, 2001
Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death.
Nadel Jay A
doaj   +1 more source

Ultrastructural and histological study of intestine of adult Nile Tilapia (Oreochromis Niloticus) [PDF]

Benha Veterinary Medical Journal
The tilapia intestine is essential for both digestion and nutrient absorption, making its structural analysis crucial for understanding its functional adaptations. This study sought to examine the histological, ultrastructural, and histochemical features
Yasmeen Ali, Aya Tantawy, Eman Khalil
doaj   +1 more source