Results 1 to 10 of about 56,340 (115)

Novel insights into the study of goblet cell hypersecretion in allergic rhinitis [PDF]

Frontiers in Immunology
Goblet cell hypersecretion is a hallmark of airway inflammation and is driven by complex neuroimmune regulation involving submucosal glands and goblet cells. Although studies have focused on mast cell degranulation as a critical driver of nasal secretion,
Xiaojia Zhu, Xiaojia Zhu, Fengli Cheng, Hongying Duan, Hongying Duan, Sirui Fu, Sirui Fu, Changqing Zhao   +7 more
doaj   +2 more sources

Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn’s Disease Is Induced by Dysbiosis and Epithelial MyD88Summary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: The role of goblet cells in small intestinal inflammation in Crohn’s disease (CD) is unknown. Polymorphisms of NOD2 confer risk for CD and associate with small intestinal disease location.
Serre-Yu Wong, Maria Manuela Estevinho, Thomas Heaney, Allison A. Marshall, Elisabeth Giselbrecht, Scott G. Daniel, Chaoting Zhou, Adriana Rosas-Villegas, Kyung Ku Jang, Hairu Yang, Huaibin Mabel Ko, John D. Paulsen, Yi Ding, Kyle Bittinger, Judy H. Cho, James D. Lewis, Deepshika Ramanan, Ken Cadwell   +17 more
doaj   +2 more sources

R0 Resection for Stage IVc Appendiceal Goblet Cell Adenocarcinoma Diagnosed after Left Adnexectomy: A Case Report [PDF]

Journal of the Anus, Rectum and Colon
The role of surgical resection in stage IV appendiceal goblet cell adenocarcinoma remains unclear. We report a case of a 44-year-old woman who underwent left adnexectomy for an ovarian tumor at another hospital. Pathological examination revealed not only
Naoki Sakuyama, Yasunori Ota, Susumu Aikou, Satoko Momma, Junko Mukohyama, Dai Shida   +5 more
doaj   +2 more sources

Goblet Cells and Mucins: Role in Innate Defense in Enteric Infections

Pathogens, 2013
Goblet cells reside throughout the gastrointestinal (GI) tract and are responsible for the production and preservation of a protective mucus blanket by synthesizing and secreting high molecular weight glycoproteins known as mucins.
Janice J. Kim, Waliul I. Khan
doaj   +3 more sources

SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways

Nature Communications, 2023
Allergic asthma is characterized by goblet cell metaplasia and subsequent mucus hypersecretion that contribute to the morbidity and mortality of this disease.
Dan Tan, Meiping Lu, Yuqing Cai, Weibo Qi, Fugen Wu, Hangyang Bao, Meiyu Qv, Qiangqiang He, Yana Xu, Xiangzhi Wang, Tingyu Shen, Jiahao Luo, Yangxun He, Junsong Wu, Lanfang Tang, Muhammad Qasim Barkat, Chengyun Xu, Ximei Wu   +17 more
doaj   +1 more source

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells

Life Science Alliance, 2022
The histone methyltransferase Mll1 controls intestinal secretory cell fate by promoting Wnt-driven Paneth and restricting Mapk-dependent goblet cell differentiation through regulation of Gata4/6 transcription factors Differentiation and lineage ...
Johanna Grinat, Frauke Kosel, Neha Goveas, Andrea Kranz, Dimitra Alexopoulou, Klaus Rajewsky, Michael Sigal, A Francis Stewart, Julian Heuberger   +8 more
doaj   +1 more source

Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments. [PDF]

PLoS ONE, 2017
PURPOSE:Modification of mucous cell density and gel-forming mucin production are established hallmarks of mucosal diseases. Our aim was to develop and validate a mouse model to study live goblet cell density in pathological situations and under ...
Céline Portal, Valérie Gouyer, Frédéric Gottrand, Jean-Luc Desseyn   +3 more
doaj   +1 more source

Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative ColitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC).
Annika Sünderhauf, Maren Hicken, Heidi Schlichting, Kerstin Skibbe, Mohab Ragab, Annika Raschdorf, Misa Hirose, Holger Schäffler, Arne Bokemeyer, Dominik Bettenworth, Anne G. Savitt, Sven Perner, Saleh Ibrahim, Ellinor I. Peerschke, Berhane Ghebrehiwet, Stefanie Derer, Christian Sina   +16 more
doaj   +1 more source

Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro

Biomedicine Hub, 2021
Introduction: Most intraocular pressure (IOP)-lowering eye drops are preserved with benzalkonium chloride (BAK). This can increase side effects and decrease adherence.
Anne Hedengran, Xenia Begun, Olivia Müllertz, Zaynab Mouhammad, Rupali Vohra, Jeffrey Bair, Darlene A. Dartt, Barbara Cvenkel, Steffen Heegaard, Goran Petrovski, Miriam Kolko   +10 more
doaj   +1 more source

Vasoactive intestinal peptide regulates ileal goblet cell production in mice

Physiological Reports, 2020
Innervation of the intestinal mucosa has gained more attention with demonstrations of tuft and enteroendocrine cell innervation. However, the role(s) these fibers play in maintaining the epithelial and mucus barriers are still poorly understood.
Luke A. Schwerdtfeger, Stuart A. Tobet
doaj   +1 more source