Novel insights into the study of goblet cell hypersecretion in allergic rhinitis [PDF]
Frontiers in ImmunologyGoblet cell hypersecretion is a hallmark of airway inflammation and is driven by complex neuroimmune regulation involving submucosal glands and goblet cells. Although studies have focused on mast cell degranulation as a critical driver of nasal secretion,
Xiaojia Zhu +7 more
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IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection. [PDF]
PLoS Pathogens, 2013 Type 2 immune responses are essential in protection against intestinal helminth infections. In this study we show that IL-22, a cytokine important in defence against bacterial infections in the intestinal tract, is also a critical mediator of anti ...
Jan-Eric Turner +2 more
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Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination [PDF]
Case Reports in Gastrointestinal Medicine, 2012 Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix.
Tine Gregersen +5 more
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Goblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn’s Disease Is Induced by Dysbiosis and Epithelial MyD88Summary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: The role of goblet cells in small intestinal inflammation in Crohn’s disease (CD) is unknown. Polymorphisms of NOD2 confer risk for CD and associate with small intestinal disease location.
Serre-Yu Wong +17 more
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R0 Resection for Stage IVc Appendiceal Goblet Cell Adenocarcinoma Diagnosed after Left Adnexectomy: A Case Report [PDF]
Journal of the Anus, Rectum and ColonThe role of surgical resection in stage IV appendiceal goblet cell adenocarcinoma remains unclear. We report a case of a 44-year-old woman who underwent left adnexectomy for an ovarian tumor at another hospital. Pathological examination revealed not only
Naoki Sakuyama +5 more
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Disease-specific transcriptional programs govern airway goblet cell metaplasia [PDF]
HeliyonHypersecretion of airway mucus caused by goblet cell metaplasia is a characteristic of chronic pulmonary inflammatory diseases including asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD).
Kuan Li +6 more
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Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis [PDF]
Gut MicrobesColonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier ...
Niloofar Mirzadzare +12 more
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Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
Life Science Alliance, 2022 The histone methyltransferase Mll1 controls intestinal secretory cell fate by promoting Wnt-driven Paneth and restricting Mapk-dependent goblet cell differentiation through regulation of Gata4/6 transcription factors Differentiation and lineage ...
Johanna Grinat +8 more
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SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways
Nature Communications, 2023 Allergic asthma is characterized by goblet cell metaplasia and subsequent mucus hypersecretion that contribute to the morbidity and mortality of this disease.
Dan Tan +17 more
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Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments. [PDF]
PLoS ONE, 2017 PURPOSE:Modification of mucous cell density and gel-forming mucin production are established hallmarks of mucosal diseases. Our aim was to develop and validate a mouse model to study live goblet cell density in pathological situations and under ...
Céline Portal +3 more
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