Results 41 to 50 of about 56,489 (258)

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Goblet Cell Carcinoid of Appendix

Journal of Cancer Research and Practice, 2014
Carcinoid tumors are rare and slow-growing malignancies which occur most frequently in the appendix as its primary malignancy. Goblet cell carcinoid belongs to a subgroup of carcinoids and occurs in exclusively the appendix.
Kung-Chen Ho, Chien-Liang Liu, Jie-Jen Lee, Tsan-Pai Liu, Wen-Chin Ko, Jiunn-Chang Lin   +5 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.

PLoS ONE, 2014
Hirschsprung disease-associated enterocolitis (HAEC) leads to significant mortality and morbidity, but its pathogenesis remains unknown. Changes in the colonic epithelium related to goblet cells and the luminal mucus layer have been postulated to play a ...
Jay R Thiagarajah, Hasan Yildiz, Taylor Carlson, Alyssa R Thomas, Casey Steiger, Alberto Pieretti, Lawrence R Zukerberg, Rebecca L Carrier, Allan M Goldstein   +8 more
doaj   +1 more source

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

Biology Open, 2012
Summary Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate.
Olivier Boucherat, Jamila Chakir, Lucie Jeannotte   +2 more
doaj   +1 more source

ON THE SITE OF SULFATION IN COLONIC GOBLET CELLS [PDF]

The Journal of Cell Biology, 1964
The location of bound S35 in the goblet cell of the rat colon at time points from 2 to 60 minutes after administration of S35 as sodium sulfate has been observed in vivo and in vitro by radioautographic techniques. Grains were first observed by electron microscopy over the stacked lamellae of the paranuclear part of the Golgi apparatus.
N, LANE, L, CARO, L R, OTERO VILARDEBO, G C, GODMAN   +3 more
openaire   +2 more sources

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination

Case Reports in Gastrointestinal Medicine, 2012
Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix.
Tine Gregersen, Nanna Holt, Henning Gronbaek, Ida Vogel, Lars J. Jørgensen, Klaus Krogh   +5 more
doaj   +1 more source

Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture

BMJ Open Ophthalmology, 2020
Objective To determine the effect of povidone iodine (PI), an antiseptic commonly used prior to ocular surgery, on viability of mixed populations of conjunctival stratified squamous and goblet cells, purified conjunctival goblet cells and purified ...
Miriam Kolko, William Swift, Jeffrey A Bair, Wanxue Chen, Michael Li, Sole Lie, Dayu Li, Menglu Yang, Marie A Shatos, Robin R Hodges, Tor P Utheim, Wendell Scott, Darlene A Dartt   +12 more
doaj   +1 more source

Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice

Frontiers in Physiology, 2021
Excessive mucus production is a major feature of allergic asthma. Disruption of epithelial junctions by allergens such as house dust mite (HDM) results in the activation of β-catenin signaling, which has been reported to stimulate goblet cell ...
Virinchi N. S. Kuchibhotla, Virinchi N. S. Kuchibhotla, Virinchi N. S. Kuchibhotla, Virinchi N. S. Kuchibhotla, Malcolm R. Starkey, Malcolm R. Starkey, Malcolm R. Starkey, Andrew T. Reid, Andrew T. Reid, Irene H. Heijink, Irene H. Heijink, Irene H. Heijink, Martijn C. Nawijn, Martijn C. Nawijn, Philip M. Hansbro, Philip M. Hansbro, Philip M. Hansbro, Philip M. Hansbro, Darryl A. Knight, Darryl A. Knight, Darryl A. Knight, Darryl A. Knight   +21 more
doaj   +1 more source