Results 61 to 70 of about 89,931 (296)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.

PLoS ONE, 2014
Hirschsprung disease-associated enterocolitis (HAEC) leads to significant mortality and morbidity, but its pathogenesis remains unknown. Changes in the colonic epithelium related to goblet cells and the luminal mucus layer have been postulated to play a ...
Jay R Thiagarajah, Hasan Yildiz, Taylor Carlson, Alyssa R Thomas, Casey Steiger, Alberto Pieretti, Lawrence R Zukerberg, Rebecca L Carrier, Allan M Goldstein   +8 more
doaj   +1 more source

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

Biology Open, 2012
Summary Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate.
Olivier Boucherat, Jamila Chakir, Lucie Jeannotte   +2 more
doaj   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Spatial Detection of Microsphere Polystyrene Plastics and Molecular Remodeling within a Full‐Body Mouse with MALDI Trapped Ion Mobility Mass Spectrometry Imaging

Angewandte Chemie, EarlyView.
Orally administered polystyrene microplastics accumulate in murine tissues and are detected using MALDI‐MSI with TIMS. Lipid profiling reveals decreases in hexosylceramides, sphingomyelins, and ether‐linked phospholipids, indicating altered metabolism.
Karina A. Vargas, Amy L. Parkhurst, Ming‐Fo Hsu, Christopher Hou, Fawaz G. Haj, Elizabeth K. Neumann   +5 more
wiley   +2 more sources

Goblet Cell Carcinoid of Appendix

Journal of Cancer Research and Practice, 2014
Carcinoid tumors are rare and slow-growing malignancies which occur most frequently in the appendix as its primary malignancy. Goblet cell carcinoid belongs to a subgroup of carcinoids and occurs in exclusively the appendix.
Kung-Chen Ho, Chien-Liang Liu, Jie-Jen Lee, Tsan-Pai Liu, Wen-Chin Ko, Jiunn-Chang Lin   +5 more
doaj   +1 more source

Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice

Frontiers in Physiology, 2021
Excessive mucus production is a major feature of allergic asthma. Disruption of epithelial junctions by allergens such as house dust mite (HDM) results in the activation of β-catenin signaling, which has been reported to stimulate goblet cell ...
Virinchi N. S. Kuchibhotla, Virinchi N. S. Kuchibhotla, Virinchi N. S. Kuchibhotla, Virinchi N. S. Kuchibhotla, Malcolm R. Starkey, Malcolm R. Starkey, Malcolm R. Starkey, Andrew T. Reid, Andrew T. Reid, Irene H. Heijink, Irene H. Heijink, Irene H. Heijink, Martijn C. Nawijn, Martijn C. Nawijn, Philip M. Hansbro, Philip M. Hansbro, Philip M. Hansbro, Philip M. Hansbro, Darryl A. Knight, Darryl A. Knight, Darryl A. Knight, Darryl A. Knight   +21 more
doaj   +1 more source

Autoimmune Enteropathy with Goblet-Cell Antibodies [PDF]

Journal of the Royal Society of Medicine, 1999
Boari flap was undertaken, and histological examination confirmed the presence of a single pTaG 1 papillary transitional cell carcinoma in the lower third of the ureter. Subsequent cystoscopies at three and six months were normal. One year after the surgical procedure the patient developed painless haematuria.
D, Rogahn, C P, Smith, A, Thomas
openaire   +2 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture

BMJ Open Ophthalmology, 2020
Objective To determine the effect of povidone iodine (PI), an antiseptic commonly used prior to ocular surgery, on viability of mixed populations of conjunctival stratified squamous and goblet cells, purified conjunctival goblet cells and purified ...
Miriam Kolko, William Swift, Jeffrey A Bair, Wanxue Chen, Michael Li, Sole Lie, Dayu Li, Menglu Yang, Marie A Shatos, Robin R Hodges, Tor P Utheim, Wendell Scott, Darlene A Dartt   +12 more
doaj   +1 more source