Results 81 to 90 of about 89,931 (296)

Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine [PDF]

, 2017
Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin
Aladegbami, Bola, Bao, James, Barron, Lauren, Colasanti, Jason, Erwin, Christopher R, Guo, Jun, Warner, Brad W   +6 more
core   +2 more sources

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. [PDF]

, 2013
Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects.
Bratt, Jennifer M, Franzi, Lisa M, Kenyon, Nicholas J, Lam, Kit S, Lee, Joyce, Luo, Juntao, Zeki, Amir A   +6 more
core   +2 more sources

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease

Frontiers in Immunology, 2018
Background: Mucosal IL-13 Receptor alpha 2 (IL13RA2) mRNA expression is one of the best predictive markers for primary non-responsiveness to infliximab therapy in patients with inflammatory bowel disease (IBD).
Bram Verstockt, Bram Verstockt, Clémentine Perrier, Clémentine Perrier, Gert De Hertogh, Jonathan Cremer, Jonathan Cremer, Brecht Creyns, Brecht Creyns, Gert Van Assche, Gert Van Assche, Marc Ferrante, Marc Ferrante, Jan L. Ceuppens, Séverine Vermeire, Séverine Vermeire, Christine Breynaert   +16 more
doaj   +1 more source

Serum antibodies in first-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years [PDF]

, 2005
Introduction: Various disease-specific serum antibodies were described in patients with inflammatory bowel disease and their yet healthy first-degree relatives.
Bansi DS, C. Brückl, C. Folwaczny, Cambridge G, Colombel JF, Folwaczny C, Folwaczny C, Folwaczny C, Folwaczny C, Glas J, H.C. Hollay, H.P. Török, Hoffman IE, J. Glas, Klebl FH, Klebl FH, L. Tonenchi, Lombardi G, M. Folwaczny, M. Osthoff, Quinton JF, R. Gruber, Ruemmele FM, Seibold F, Seibold F, Shanahan F, Shanahan F, T. Mussack, Torok HP, Torok HP   +29 more
core   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators

Scientific Reports, 2018
In the eye, goblet cells responsible for secreting mucins are found in the conjunctiva. When mucin production is not tightly regulated several ocular surface disorders may occur.
Laura García-Posadas, Robin R. Hodges, Yolanda Diebold, Darlene A. Dartt   +3 more
doaj   +1 more source

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

Clinical Epigenetics, 2017
Background Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients.
J. Song, I. H. Heijink, L. E. M. Kistemaker, M. Reinders-Luinge, W. Kooistra, J. A. Noordhoek, R. Gosens, C. A. Brandsma, W. Timens, P. S. Hiemstra, M. G. Rots, M. N. Hylkema   +11 more
doaj   +1 more source