Results 101 to 110 of about 56,489 (258)

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

Cellular Toxicity of Short‐ and Long‐Term Exposures to Polystyrene Nanoplastics and Microplastics in Fish Skin Cell Derived From Fathead Minnow (Pimephales promelas)

Journal of Applied Toxicology, EarlyView.
ABSTRACT The ubiquitous presence of microplastics and nanoplastics (MNPs) is raising concerns about their impact on the health of humans and other living organisms. Due to its tiny size, this particle can accumulate and circulate in the body after uptake, resulting in a variety of harmful outcomes on the organism, such as increased oxidative stress and
Trang Thi Nguyen, Kiyun Park, Ihn‐Sil Kwak   +2 more
wiley   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

Congenital short bowel syndrome: Clinical aspects by systematic review

JPGN Reports, EarlyView.
Abstract Objectives Congenital short bowel syndrome (CSBS) is a rare intestinal disorder characterized by inborn shortening of the bowel with mainly mutations in Coxsackie and Adenovirus receptor‐like membrane protein (CLMP) and Filamin A (FLNA) genes.
Barblin Remund, Susanne Schibli, Christiane Sokollik   +2 more
wiley   +1 more source

Effect of Notch1 on Vocal Fold Re‐Epithelization After Acute Injury

The Laryngoscope, EarlyView.
Conditional deletion of Notch1 in Lrig1‐expressing vocal fold epithelial cells impaired re‐epithelialization following naphthalene injury, resulting in sustained basal cell proliferation, abnormal epithelial differentiation, and prolonged inflammatory cell infiltration.
Jie Cai, Susan L Thibeault, Vlasta Lungova   +2 more
wiley   +1 more source

Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease

Nature Communications
Understanding the molecular mechanisms that regulate intestinal epithelial cell (IEC) renewal provides potential targets for inflammatory bowel disease (IBD).
Qian Lin, Sudan Zhang, Jiaren Zhang, Yi Jin, Taoli Chen, Ruoyu Lin, Jiaxuan Lv, Wenjing Xu, Tianzhen Wu, Shenyu Tian, Lei Ying, Xiaokun Li, Zhifeng Huang, Jianlou Niu   +13 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma

The Journal of Pathology, EarlyView.
Abstract Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct subtype of lung adenocarcinoma with unique clinicopathologic features; however, its histogenesis remains incompletely understood. Although mucinous metaplasia has been suspected as a precursor lesion, direct molecular evidence supporting this progression is limited. In this study,
Joon Young Park, Do Yeon Kim, Hyun Jung Lee, Jung Hee Lee, Hae Ryoun Park, Dong Hoon Shin   +5 more
wiley   +1 more source