Results 111 to 120 of about 56,489 (258)

Rethinking colitis: MrgprD puts macrophages in the driver's seat†

The Journal of Pathology, EarlyView.
Abstract There is increasing evidence to suggest that dysregulated macrophages play an important role in the promotion and maintenance of inflammatory bowel disease (IBD), yet the underlying mechanisms remain unclear. A recent study published by Lv, Xia, Qiao et al in The Journal of Pathology investigated the role of Mas‐related G protein‐coupled ...
Kolja Pocha, Konstantin Bräutigam
wiley   +1 more source

Goblet Cell [PDF]

, 2020
openaire   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Breaking Alzheimer's Disease Barrier: The Role of Xanthoceras sorbifolia Bunge Oil in Gut‐Brain Axis and TLR4/Myd88/MAPK Pathway Inhibition

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and neuroinflammation. Xanthoceras sorbifolia Bunge oil (XSBO), a woody plant oil rich in bioactive fatty acids, has shown potential health benefits.
Lijing Du, Shikai Yan, Xiaopeng Ren, Syed Shams ul Hassan, Yuanfang Sun, Yu Gan, Xue Xiao, Shasha Li, Huizi Jin   +8 more
wiley   +1 more source

Astrovirus infection dysregulates goblet cell-associated antigen passages. [PDF]

iScience
Gulman J, Heredia-Osuna N, Ohanyan M, Poot A, Vargas C, Auerbuch V, McDonald KG, Newberry RD, Cortez V.   +8 more
europepmc   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Impact of BECLIN1 haploinsufficiency on goblet cell function and susceptibility to colitis. [PDF]

Cell Death Dis
Juliani J, Tran S, Harris TJ, Ellis SL, Al-Ani AH, Wijebandara Y, Patel KM, Young SN, Evangelista M, Baloyan D, Reehorst CM, Nightingale R, Jenkins LJ, De Cruz P, Duszyc K, Kile BT, Yap AS, Mariadason JM, Christensen B, Samson AL, Murphy JM, Fairlie WD, Lee EF.   +22 more
europepmc   +1 more source

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

Phytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei, Hong‐Ping Wen, Jian‐Bo Song, Jin‐Fang Xu, Hong‐Rui Guo   +4 more
wiley   +1 more source

TRPC6 mediates goblet cell differentiation in COPD. [PDF]

Respir Res
Li H, Hu G, Huang L, Yi E, Di N, Li J, Hu C, Che L, Huang Y, Wang J, Wen Q, Yang X, Liu Y, Bai G, Lu X, Cao W, Mei X, Liu X, Li P, Wu F, Hao B, Pu J, Ran X, Sun R, Hong W, Peng Y, Zhou Y, Yin W, Ran P.   +28 more
europepmc   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source