Results 131 to 140 of about 89,931 (296)

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li   +10 more
wiley   +1 more source

Morpho‐Anatomical and HPTLC Investigations of Lysimachia nummularia L. (Primulaceae) Grown in Switzerland

open access: yesMicroscopy Research and Technique, EarlyView.
This research provides a complete morphoanatomical description of Lysimachia nummularia, as well as a HPTLC profile. Standard techniques of light and scanning electron microscopies, as well as standard techniques of HPTLC, were used. ABSTRACT Primulaceae are distributed all over the world, encompassing around 2590 species.
Carolina Sabedotti   +9 more
wiley   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

open access: yesThe Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song   +6 more
wiley   +1 more source

Biomarkers of ocular surface disease using impression cytology [PDF]

open access: yes, 2017
Aronni S   +10 more
core   +2 more sources

Bacillus thuringiensis and its pest control potential as endophyte

open access: yesPest Management Science, EarlyView.
Bacillus thuringiensis (Bt) systemically colonizes tomato plants as endophyte, inducing midgut damage, fitness reduction and immune suppression in Spodoptera littoralis larvae feeding on Bt‐colonized leaves. The immune suppression enhances the susceptibility to Bt treatments, allowing a synergistic dual use of Bt commercial formulations, by combined ...
Maria Giovanna De Luca   +8 more
wiley   +1 more source

Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infections. [PDF]

open access: yes, 1989
In rats respiratory tract infections due to Sendai virus and coronavirus usually are transient, but they can have long-lasting consequences when accompanied by Mycoplasma pulmonis infections.
Haskell, A, Huang, HT, McDonald, DM
core  

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

open access: yesPhytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta   +7 more
wiley   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

open access: yesRespirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Human Colitis‐on‐Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

open access: yesSmall, EarlyView.
This study establishes a human immunocompetent colitis‐on‐chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS‐induced injury. It reveals that microbiota‐derived butyrate simultaneously stabilizes epithelial junctions and reprograms macrophages via HDAC/NLRP3‐dependent mechanisms ...
Manuel Allwang   +16 more
wiley   +1 more source

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese   +13 more
wiley   +1 more source

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