Results 171 to 180 of about 4,473,643 (292)

From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation. [PDF]

Front Immunol
Du N, Zhang K, Guo J, Yan W, Xu L.
europepmc   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

A Nutrient-Dense Diet with Optimal Protein Level Restores Goblet Cells and Alleviates Microbial Dysbiosis in a Mouse Model of Colitis. [PDF]

J Nutr
Jiang L, Li J, Pramana AA, Pan YX, Mei W, Chen H.   +5 more
europepmc   +1 more source

In vivo fluorescence imaging of conjunctival goblet cells

, 2019
2
SEUNGHUN, LEE, KIM, KI HEAN, HOONCHEOL, JANG, JUNGBIN, LEE, KIMSEONGHAN   +4 more
core  

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Goblet cells dictate viral tropism and pathogenesis in nasal and intestinal mucosae. [PDF]

Proc Natl Acad Sci U S A
Wang W, Chao W, Zeng H, Tang R, Liu R, Wang C, Wu X, Qi J, Cao Y, Li Y, Yang Q.   +10 more
europepmc   +1 more source

Negative feedback by IRE1β optimizes mucin production in goblet cells [PDF]

In mammals, the prototypical endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1 (IRE1) has diverged into two paralogs. IRE1α is broadly expressed and mediates the unconventional splicing of X-box binding protein 1 (XBP1) mRNA during ER ...
Ron, David, 23254, Kohno, Kenji, 23255, 23256, Nakamura, Daisuke, 23257, 23258, Takahashi, Satsuki, 23259, Kadokura, Hiroshi, 23260, Iwawaki, Takao, 23261, 23262, 23253, Tsuru, Akio, Iwano, Megumi, Fujimoto, Naoko, Saito, Michiko   +19 more
core  

m6A‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

Allergy, EarlyView.
This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in HDM‐induced AR, focusing on ferroptosis‐related responses and nasal epithelial barrier disruption. HDM exposure induces lipid peroxidation‐driven ferroptosis and epithelial barrier disruption.
Zehua Lin, Baoai Han, Qiang Xie, Aikebaier Tuohuti, Weisong Cai, Peng Zhou, Jiahao Meng, Qiuyang Fu, Zuhong He, Xiong Chen   +9 more
wiley   +1 more source

A Sex-specific Role for Goblet Cells and Mucus Homeostasis in the Intestine. [PDF]

Cell Mol Gastroenterol Hepatol
Gustafsson JK, Knoop KA.
europepmc   +1 more source

Staphylococcus aureus activates NRLP3-dependent IL-1β secretion from human conjunctival goblet cells using α toxin and toll-like receptors 2 and 1. [PDF]

Front Cell Infect Microbiol, 2023
Li D, Hodges R, AukrustNaqvi M, Bair J, Bispo PJM, Gilmore MS, Gregory-Ksander M, Dartt DA.   +7 more
europepmc   +1 more source