Results 141 to 150 of about 583,034 (245)

Incidence and Predictors of Immune‐Related Hypothyroidism Under Pembrolizumab Across Gynecologic Malignancies and Melanoma: A Real‐World Cohort Study

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) frequently cause thyroid immune‐related adverse events (irAEs). Permanent hypothyroidism, the clinically most relevant phenotype, requires lifelong hormone replacement. We investigated its incidence, course, risk factors, and prognostic relevance under pembrolizumab.
Freya Koffka   +9 more
wiley   +1 more source

Early Cessation of Adjuvant Anti‐PD‐1 Therapy in Stage III and IV Melanoma

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT One year of adjuvant anti‐PD‐1 has improved disease‐free survival in Stage III melanoma. It is unknown whether shorter treatment duration affects outcomes. Real‐world data may help clarify this. In this retrospective observational study, patients with resected Stage III/IV melanoma receiving adjuvant anti‐PD‐1 in the Netherlands from 2018 to ...
Manja Bloem   +20 more
wiley   +1 more source

Young bodies, aging ovaries: A systematic review and meta‐synthesis of women's perspectives on spontaneous premature ovarian insufficiency

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives Spontaneous premature ovarian insufficiency (POI) is a condition characterized by the cessation of ovarian function before age 40, unrelated to medical interventions. It affects approximately 3.5% of women worldwide and can result in significant emotional, physical, and social consequences.
Maria Patricia Roman   +2 more
wiley   +1 more source

Solar‐driven co‐evolution of H2 and H2O2 from pure water splitting over emerging photocatalysts: Detailed mechanism and future outlook

open access: yesPhotoMat, EarlyView., 2023
Photocatalytic water splitting for co‐evolution of H2 and H2O2 is deemed as a sustainable and promising strategy to address energy and environment issues, thus receiving increasing attention and realizing continuous achievements. This review aims to offer a deep understanding of the mechanism for H2 and H2O2 co‐evolution and the design principle of ...
Qiaohong Zhu   +4 more
wiley   +1 more source

Spatiotemporal Pattern Evolution and Driving Mechanisms of World Botanical Gardens Over Five Centuries

open access: yesIntegrative Conservation, EarlyView.
This study presents a comprehensive review of the 500‐year spatiotemporal evolution of global botanical gardens, identifying three major development stages—initial exploration (1543–1699), steady expansion (1700–1899), and rapid proliferation (1900–2020)—with six distinct sub‐stages. We propose a tripartite driving framework grounded in colonial botany
Shidong Li, Guangzhen Shi, Qingwei Li
wiley   +1 more source

Adolescents' Experiences of Social Media Content Types and Wellbeing: A Photo‐Elicitation Interview Study

open access: yesJournal of Adolescence, EarlyView.
ABSTRACT Background Adolescents' experiences of social media are increasingly shaped by algorithmic recommendation systems that structure repeated exposure to diverse content types. However, research has focused predominantly on screen time, with limited attention to the diverse types of content encountered within curated feeds or how these experiences
Lizzy Winstone   +7 more
wiley   +1 more source

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