Results 111 to 120 of about 2,014,943 (251)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
DER GOING-CONCERN-GRUNDSATZ Der Going-Concern-Grundsatz ...
Hirschler, Klaus +3 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Voluntary Going Concern Disclosure and Bankruptcy Planning
, 2015 Even before the FASB issued the final standard requiring management to assess and disclose the firm’s ability to continue as a going concern, many firms voluntarily disclosed going concern doubts prior to bankruptcy. To better understand these disclosure
Ordyna, Paul E
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
KeberlanjutanThis study examines the effect of a public accounting firm's reputation and the previous year's audit opinion on going concern audit opinion. We use Indonesian property and real estate sector companies as the research sample.
Dhiya Ulhaq Taufiqurrahman +1 more
doaj
Audit Research: Some Reflections
Revista de Contabilidad: Spanish Accounting Review, 2018 This paper, which is intended to be a long editorial note, aims to examine what we know and what we need to know about the auditing activity. Its main purpose is to point out research areas that allow us to learn something more about the auditor's ...
Jose Antonio Gonzalo Angulo, Dr. +1 more
doaj
Improving the prediction of going concern of Taiwanese listed companies using a hybrid of LASSO with data mining techniques. [PDF]
Springerplus, 2016 Goo YJ, Chi DJ, Shen ZD.
europepmc +1 more source