Results 31 to 40 of about 1,904,425 (304)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Overcoming barriers and enabling artificial intelligence adoption in allied health clinical practice: A qualitative study

Digital Health
Background Artificial intelligence (AI) has the potential to revolutionise healthcare. If the implementation is successful it has the potential to improve healthcare outcomes for patients and organisations. Little is known about the perceptions of allied
Jane Hoffman, Rachel Wenke, Rebecca L Angus, Lucy Shinners, Brent Richards, Laetitia Hattingh   +5 more
doaj   +1 more source

The Kumtor gold deposit in the Middle Tien Shan, Kyrgyzstan, and the application of 3-D modeling in Seequent’s Leapfrog Geo software for the geological exploration

Руды и металлы, 2023
The Kumtor deposit is one of the largest gold deposits in the Tien Shan. The ore zones are localized in rocks of the black shale formation, in an amagmatic gently dipping structure.
Shevkunov A. G., Kornitsky A. I., Bashkirov A. P., Aidarkulov T. N.   +3 more
doaj   +1 more source

Gold and gold alloy foams

, 2022
S.251-256The possibilities to manufacture gold-based foams are explored. Gold powder and various powdered alloying elements are mixed with a small volume fraction of a gas-releasing blowing agent The blend is compacted to a dense precursor, which is then
Banhart, J.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Ligamentous Injuries in Stable Ankle Fractures: An MRI-Based Study

Foot & Ankle Orthopaedics
Background: Ankle fractures are common orthopaedic injuries, and their management is primarily determined by fracture stability. The Lauge-Hansen classification system categorizes fractures according to mechanism of injury and ligaments involved ...
Alex N. Karanja MBChB, Albert Ho-Huynh MBBS, Tom Walsh PhD, Simon R. Platt MBChB, FRCS, FRACS, FAOrthoA   +3 more
doaj   +1 more source

Septal Myocarditis Mimicking Proximal Left Anterior Descending Artery Occlusion

JACC: Case Reports
Background: Acute myocarditis is a recognized ST-segment elevation myocardial infarction mimic; however, focal septal myocarditis presenting with a proximal left anterior descending artery infarction phenotype is uncommon. Case Summary: A previously well
Stefany Youngsoo Jeong, MD, Sisijaya Vinura Jayawardena, MBBS, Nicholas Seton, MD, Matthew Lim, MBBS, Joshua Martin, MBChB, Maria Gabriela Matta, MD, MSc   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source