Results 41 to 50 of about 1,302,837 (318)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
The Mineralogy Characteristics of Overflow Product from Hydrocyclone in the Jiaojia Gold Mine
Yankuang ceshi, 2014 The capacity of ore treatment reached 12,000 t/d and gold recovery achieved 92% in the Jiaojia Gold Mine. Broken product has been washed with double spiral classifier, and the ore slime yield was 7%.
HU Hai-xiang +5 more
doaj +2 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Frontiers in GastroenterologyPatients with ulcerative colitis (UC) are at an increased risk of colorectal cancer (CRC), which is compounded in the presence of other risk factors such as primary sclerosing cholangitis (PSC) and stricture.
Daniel Chorley +4 more
doaj +1 more source
BMJ, 2002 The chancellor's budget statement sets out plans for unprecedented rates of growth in NHS spending over the medium term. Responding to the Wanless review team's challenge on the long term funding needs of the NHS,1 the chancellor's special, five year settlement for the NHS will mean an extra 7.4% real terms expenditure each year over the period 2003-4 ...
openaire +3 more sources
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Journal of Perioperative Nursing, 2019 Objective: To describe changes in day of surgery (DOS) cancellations and procedural delays following introduction of a practice improvement intervention to improve team members’ participation in the surgical safety checklist (SSC).
Brigid Gillespie +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report
Frontiers in MedicineSpontaneous splenic rupture (SSR) is an exceptionally rare and life-threatening condition, with its pathophysiology remaining poorly understood. This report describes the first documented case of SSR in a patient with Q fever infection and underlying ...
Cecil Mustafiz +5 more
doaj +1 more source