Results 31 to 40 of about 280 (249)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
CURRENT ISSUES OF SEARCH OF GOLD PLACERS IN THE SOUTH OF UKRAINE
Геологія і корисні копалини Світового океану, 2020 The main gold ore territory of Ukraine is Ukrainian shield, mainly its central and eastern parts. Currently, the potential of Ukrainian shield is estimated at 2.4 thousand tons of gold.
I.E. Lomakin +2 more
doaj +1 more source
Руды и металлы, 2023 Because of significant exhaustion of known easily accessible gold placers, revealing new such objects is becoming increasingly important. Several gold placer clusters are situated in the region of the Selennyakh River in the middle course of the ...
Vladimirtseva O. V. +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Russian Journal of Earth SciencesThe article is dedicated to estimation of tertiary terrigenous strata role in world gold mining. Localization peculiarities of tertiary gold deposits and their placers were examined.
Vladimirceva Ol'ga +3 more
doaj +1 more source
BLACK SEA: THE FUTURE OF THE MINERAL RESOURCE BASE [PDF]
Геологія і корисні копалини Світового океану, 2019 The article considers possible ways of geological study and development of the mineral raw material complex of the Black Sea, in particular, the energy complex, oolite iron ores, building materials, mineral fertilizers, fresh water, titanium zirconium ...
Ye.F. Shnyukov
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Managing in situ gold concentrations in placers [PDF]
International Journal of Mining and Geo-Engineering, 2015 In studying of the in situ gravitational concentration process part feature for placer, the technological ability to transform the in situ massif placer structure is evident.
Alexandr Mikhailov
doaj