Results 31 to 40 of about 6,618 (292)

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel   +3 more
wiley   +1 more source

Dzheltulak system of the Oktyabrsky ore-placer node of the Amur gold-bearing province

open access: yesИзвестия высших учебных заведений: Геология и разведка
Background. Information on the Dzheltulak large placer system of the Amur gold-bearing province, which has produced 80 tons of gold, is presented. Aim. To determine the geological and structural position of the Dzheltulak placer system, one of the most ...
V. A. Stepanov, A. V. Melnikov
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Material characteristic of Vetvisty creek placer gold and prospects for atypical-source deposits in the middle course of the Selennyakh river (Momsky and Abyisky district, Yakutia)

open access: yesИзвестия высших учебных заведений: Геология и разведка
Background. The lower-middle course of the Selennyakh River in the Momsky and Abyisky districts of the Republic of Sakha, Yakutia, is characterized by a wide distribution of alluvial gold placers. The absence of obvious potential primary sources of these
A. M. Prasolov, O. V. Vladimirtseva
doaj   +1 more source

A four stage evolution of the White Channel gravel: Implications for stratigraphy and palaeoclimates [PDF]

open access: yes, 2014
Although the White Channel gravel (WCG) of the Klondike district, Yukon, contains gold placers which have been exploited for over a century, few sedimentological studies have been undertaken.
Chapman, Robert   +3 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Composition and gold-bearing potential of Neogene deposits in the middle reaches of the Selennyakh river, Republic of Sakha (Yakutia)

open access: yesРуды и металлы, 2023
Because of significant exhaustion of known easily accessible gold placers, revealing new such objects is becoming increasingly important. Several gold placer clusters are situated in the region of the Selennyakh River in the middle course of the ...
Vladimirtseva O. V.   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

CURRENT ISSUES OF SEARCH OF GOLD PLACERS IN THE SOUTH OF UKRAINE

open access: yesГеологія і корисні копалини Світового океану, 2020
The main gold ore territory of Ukraine is Ukrainian shield, mainly its central and eastern parts. Currently, the potential of Ukrainian shield is estimated at 2.4 thousand tons of gold.
I.E. Lomakin   +2 more
doaj   +1 more source

BLACK SEA: THE FUTURE OF THE MINERAL RESOURCE BASE [PDF]

open access: yesГеологія і корисні копалини Світового океану, 2019
The article considers possible ways of geological study and development of the mineral raw material complex of the Black Sea, in particular, the energy complex, oolite iron ores, building materials, mineral fertilizers, fresh water, titanium zirconium ...
Ye.F. Shnyukov
doaj   +1 more source

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