Results 61 to 70 of about 2,399,802 (303)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Gold Standard Gravity [PDF]

open access: yes
This paper provides striking confirmation of the restrictions of the structural gravity model of trade. Structural forces predicted by theory explain 95% of the variation of the fixed effects used to control for them in the recent gravity literature ...
James E. Anderson, Yoto V. Yotov
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Gold, fiat money and price stability [PDF]

open access: yes
The classical gold standard has long been associated with long-run price stability. But short-run price variability led critics of the gold standard to propose reforms that look much like modern versions of price-path targeting. This paper uses a dynamic
Michael D. Bordo   +2 more
core   +3 more sources

Multinomial tree models for assessing the status of the reference in studies of the accuracy of tools for binary classification

open access: yesFrontiers in Psychology, 2013
Studies that evaluate the accuracy of binary classification tools are needed. Such studies provide 2x2 cross-classifications of test outcomes and the categories according to an unquestionable reference (or gold standard).
Juan eBotella   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

On the Gold Standard for Security of Universal Steganography [PDF]

open access: yes, 2018
While symmetric-key steganography is quite well understood both in the information-theoretic and in the computational setting, many fundamental questions about its public-key counterpart resist persistent attempts to solve them.
A Kiayias   +30 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Performance of the Tariff Method: validation of a simple additive algorithm for analysis of verbal autopsies

open access: yesPopulation Health Metrics, 2011
Background Verbal autopsies provide valuable information for studying mortality patterns in populations that lack reliable vital registration data.
Murray Christopher JL   +2 more
doaj   +1 more source

Floating against the tide : Spanish monetary policy, 1870-1931 [PDF]

open access: yes
The gold standard began to emerge as a universal monetary system in the late 1870s, and it had spread throughout the world economy by 1900. It was unusual for nations to be off the gold standard, and it meant that they were detached from the ...
Elena Martínez Ruiz   +2 more
core  

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