Results 61 to 70 of about 5,097,894 (259)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Paper Money but a Gold Debt. Italy in the Gold Standard [PDF]

During the 52 years between the Unification of the Kingdom of Italy and World War 1, the lira was legally convertible into metal for a limited period of time.
Giuseppe Tattara, or consequences)
core  

Population Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets [PDF]

, 2011
Background: Verbal autopsy methods are critically important for evaluating the leading causes of death in populations without adequate vital registration systems.
Baqui, Abdullah, Kumar, Vishwajeet, Gómez Sara, Romero, M., Bruce Neal, Lucero, M, Ramírez-Villalobos Dolores, Ahuja Ramesh, Gómez, S, Ali Said, Christopher JL Murray, Romero, M, Lozano, Rafael, Baqui Abdullah, Joshi, R., Hernández, B, Marilla Lucero, Murray, Christopher Jl, Premji, Z., Dhingra, U, Riley, Ian, Flaxman, AD, Gomez, Sara, Premji, Zul, Mehta, S., Riley, I., Neal, B., Sara Gómez, Henry Kalter, Rajendra Prasad, Dantzer, Emily, Dandona, L., Ahuja, R, Hazel Remolador, Black, R., Dhingra, U., Neal, Bruce, Remolador Hazel, Flaxman, Abraham D., Praveen, Devarsetty, Das, Vinita, Tallo, V., Bernardo Hernández, Sanvictores, D., Tallo, Veronica, Lopez Alan D, Romero Minerva, Murray, C.J.L., Dutta, A, Sanvictores, D, Dhingra, Usha, Ramirez-Villalobos, D., Baqui, A, Premji, Z, Dhingra Usha, Praveen Devarsetty, Dutta, Arup, Ramirez-Villalobos, Dolores, Gomez, S., Prasad, R., Wafaie Fawzi, Zul Premji, Ohno, S.L., Lozano, R, Alan D Lopez, Dandona Lalit, Black, R, Mehta, Saurabh, Vishwajeet Kumar, Saurabh Mehta, Dandona, L, Arup Dutta, Dantzer Emily, Diozele Sanvictores, Tallo Veronica, Dolores Ramírez-Villalobos, Lucero Marilla, Murray Christopher JL, Dantzer, E, Fawzi, Wafaie, Remolador, H., Sazawal Sunil, Emily Dantzer, Sanvictores Diozele, Hernandez, B., Mehta Saurabh, Tallo, V, Sazawal, S, Romero, Minerva, Kumar Aarti, Rohina Joshi, Kumar, V., Said, M., Said Mwanaidi, Ramesh Ahuja, Riley Ian, Kumar, A, Mwanaidi Said, Ramírez-Villalobos, D, Das, Vanita, Lucero, M., Neal Bruce, Kalter Henry, Fawzi Wafaie, Said, Mwanaidi, Said, M, Aarti Kumar, Das, V., Prasad Rajendra, Baqui, A., Fawzi, W, Prasad, R, Praveen, D, Remolador, Hazel, Ali, S.M., Sazawal, S., Kumar Vishwajeet, Black Robert, Ohno, SL, Ali, Said Mohd, Lopez, Alan D., Hernandez, Bernardo, Dutta Arup, Lozano, R., Ohno Summer, Ahuja, R., Mehta, S, Usha Dhingra, Das, V, Flaxman, A.D., Said Mohd Ali, Das Vinita, Lucero, Marilla, Praveen, D., Neal, B, Joshi Rohina, Dandona, Lalit, Ahuja, Ramesh, Joshi, Rohina, Kumar, A., Ohno, Summer I., Flaxman, Abraham D, Fawzi, W., Minerva Romero, Ali, SM, Dantzer, E., Lalit Dandona, Ramírez-Villalobos10, D., Vinita Das, Remolador, H, Dutta, A., Veronica Tallo, Robert Black, Ohno, Summer Lockett, Premji Zul, Rafael Lozano, Abdullah Baqui, Murray, CJL, Prasad, Rajendra, Joshi, R, Hernández Bernardo, Black, Robert, Sanvictores, Diozele, Lopez, Alan D, Lozano Rafael, Kumar, Aarti, Sazawal, Sunil, Summer Lockett Ohno, Lopez, AD, Flaxman Abraham D, Ian Riley, Riley, I, Murray, Christopher J. L., Devarsetty Praveen, Kumar, V, Abraham D Flaxman, Kalter, Henry, Sunil Sazawal, Ali, Said M., Kalter, H, Kalter, H., Lopez, A.D.   +181 more
core   +2 more sources

An economic evaluation by a "money doctor": what Led Edwin Walter Kemmerer to Türkiye?

Trakya Üniversitesi İktisadi ve İdari Bilimler Fakültesi E-Dergi
The early 1930s saw Türkiye reaching out to numerous influential economists. Türkiye received recommendations from those economists to embrace the classical economics that was effective in the pre-1914 era. The proposed strategies urged Türkiye to uphold
Emrah Yıldız
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Performance of the Tariff Method: validation of a simple additive algorithm for analysis of verbal autopsies

Population Health Metrics, 2011
Background Verbal autopsies provide valuable information for studying mortality patterns in populations that lack reliable vital registration data.
Murray Christopher JL, Flaxman Abraham D, James Spencer L   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Gold, fiat money and price stability [PDF]

The classical gold standard has long been associated with long-run price stability. But short-run price variability led critics of the gold standard to propose reforms that look much like modern versions of price-path targeting. This paper uses a dynamic
Michael D. Bordo, Robert Dittmar, William T. Gavin   +2 more
core   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source