Results 81 to 90 of about 6,672,830 (309)

The Gold Standard Paradox in Digital Image Analysis: Manual Versus Automated Scoring as Ground Truth.

Archives of Pathology & Laboratory Medicine, 2017
CONTEXT - Novel therapeutics often target complex cellular mechanisms. Increasingly, quantitative methods like digital tissue image analysis (tIA) are required to evaluate correspondingly complex biomarkers to elucidate subtle phenotypes that can inform ...
F. Aeffner, K. Wilson, N. Martin, Joshua C. Black, C. L. Hendriks, B. Bolon, D. Rudmann, R. Gianani, Sally R. Koegler, Joseph S. Krueger, G. D. Young   +10 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Performance of the Tariff Method: validation of a simple additive algorithm for analysis of verbal autopsies

Population Health Metrics, 2011
Background Verbal autopsies provide valuable information for studying mortality patterns in populations that lack reliable vital registration data.
Murray Christopher JL, Flaxman Abraham D, James Spencer L   +2 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

From the Banks of the Orkhon to the Banks of the Neva: the History of Mining and Transit of Mongolian Gold to the Russian Empire at the beginning of the 20th century.

Монголоведение
Introduction. This scientific study examines the history of the organization of gold mining in a Russian company — the Joint Stock Company of Mining of the Tushetukhanovsky and Tsetsenkhanovsky aimags in Mongolia (“Mongolor”).
Aldar A. Shirapov, Anna M. Plekhanova
doaj   +1 more source

Quantum chemical benchmark databases of gold-standard dimer interaction energies [PDF]

, 2021
Alexander Donchev, Andrew G. Taube, Elizabeth Decolvenaere, Cory Hargus, Robert T. McGibbon, Ka-Hei Law, Brent A. Gregersen, Je-Luen Li, Kim Palmö, Karthik Siva, Michael Bergdorf, John L. Klepeis, David E. Shaw   +12 more
openalex   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Is human classification by experienced untrained observers a gold standard in fixation detection?

Behavior Research Methods, 2017
Manual classification is still a common method to evaluate event detection algorithms. The procedure is often as follows: Two or three human coders and the algorithm classify a significant quantity of data.
I. Hooge, D. Niehorster, M. Nyström, Richard Andersson, R. Hessels   +4 more
semanticscholar   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Autogenous bone grafts in oral implantology—is it still a “gold standard”? A consecutive review of 279 patients with 456 clinical procedures

International Journal of Implant Dentistry, 2017
BackgroundThis study assessed the clinical outcomes of graft success rate and early implant survival rate after preprosthetic alveolar ridge reconstruction with autologous bone grafts.MethodsA consecutive retrospective study was conducted on all patients
A. Sakkas, F. Wilde, M. Heufelder, K. Winter, A. Schramm   +4 more
semanticscholar   +1 more source