Results 21 to 30 of about 283,476 (268)
Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2
Nature Communications, 2021 Until today effective antivirals for COVID-19 treatment are not widely available. Here, Zhao et al. characterize a dual-functional cross-linking peptide, 8P9R, that can inhibit SARS-CoV-2 virus entry in vitro and suppresses viral replication in vivo in ...
Hanjun Zhao +15 more
doaj +1 more source
Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis
Biology, 2021 Cholesterol homeostasis in the retina, a sensory organ in the back of the eye, has been studied in mice but not hamsters, despite the latter being more similar to humans than mice with respect to their whole-body cholesterol maintenance. The goal of this
Nicole El-Darzi +6 more
doaj +1 more source
Clinical Infectious Diseases, 2020 Background A physiological small animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between angiotensin-converting enzyme 2 (ACE2) of common laboratory mammals and the receptor-binding domain of ...
J. Chan +23 more
semanticscholar +1 more source
Comprehensive Transcriptome Analyses of the Fructose-Fed Syrian Golden Hamster Liver Provides Novel Insights into Lipid Metabolism. [PDF]
PLoS ONE, 2016 Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes.
Ziyang Li +11 more
doaj +1 more source
mBio, 2021 There is growing evidence that coronavirus disease 2019 (COVID-19) affects males more severely than females, including compelling evidence indicating that biological sex is an important clinical factor influencing disease pathology and outcomes. In their
Rafael Tomoya Michita +1 more
doaj +1 more source
Efficient gene targeting in golden Syrian hamsters by the CRISPR/Cas9 system. [PDF]
PLoS ONE, 2014 The golden Syrian hamster is the model of choice or the only rodent model for studying many human diseases. However, the lack of gene targeting tools in hamsters severely limits their use in biomedical research.
Zhiqiang Fan +8 more
doaj +1 more source
Generation of transgenic golden Syrian hamsters [PDF]
Cell Research, 2014 Golden Syrian hamsters are small rodents, but they display many features that resemble the physiology and metabolism of humans. Hamsters have been widely used in many research areas, including carcinogenesis1, reproduction2, virology3, diabetes4 and cardiovascular diseases5.
Gao, Mingming +12 more
openaire +2 more sources
Intussusception in the Syrian Golden hamster [PDF]
British Journal of Nutrition, 1990 Of a series of ninety-six young male Syrian Golden hamsters, 13% developed lethargy, anorexia, diarrhoea and colocolic intussusception when their diet was changed from a basal laboratory-grade rodent chow to a nutritionally complete semi-purified diet. Histologically, the colon of the hamsters with intussusception had markedly reduced mucus production.
S C, Cunnane, S R, Bloom
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Sequencing, annotation and analysis of the Syrian hamster (Mesocricetus auratus) transcriptome. [PDF]
PLoS ONE, 2014 BACKGROUND:The Syrian hamster (golden hamster, Mesocricetus auratus) is gaining importance as a new experimental animal model for multiple pathogens, including emerging zoonotic diseases such as Ebola.
Nicolas Tchitchek +8 more
doaj +1 more source
Nature Communications, 2022 Since the emergence of SARS-CoV-2 several variants of concerns have been identified, with altered disease progression and transmission dynamics. Here, Armando et al.
Federico Armando +14 more
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