Results 41 to 50 of about 283,476 (268)
Use of hamster as a model to study diet-induced atherosclerosis
Nutrition & Metabolism, 2010 Golden-Syrian hamsters have been used as an animal model to assess diet-induced atherosclerosis since the early 1980s. Advantages appeared to include a low rate of endogenous cholesterol synthesis, receptor-mediated uptake of LDL cholesterol, cholesteryl
Lichtenstein Alice H +2 more
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Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR/Cas9 system
Animal Models and Experimental Medicine, 2023 Background SHARPIN (SHANK‐associated RH domain interactor) is a component of the linear ubiquitination complex that regulates the NF‐κB signaling pathway. To better understand the function of SHARPIN, we sought to establish a novel genetically engineered
Jinxin Miao +11 more
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Microbiology Spectrum, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible respiratory pathogen whose main transmission route is respiratory droplets and/or aerosols.
Philip J. Kuehl +7 more
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Nutrition & Metabolism, 2007 Background Bio F1B hamster is an inbred hybrid strain that is highly susceptible to diet-induced atherosclerosis. We previously reported that feeding a high fat fish oil diet to Bio F1B hamster caused severe hyperlipidaemia. In this study we compared the
Cornish Marion L, Cheema Sukhinder
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Biology, 2022 Assessments of sperm performance are valuable tools for the analysis of sperm fertilizing potential and to understand determinants of male fertility. Hamster species constitute important animal models because they produce sperm cells in high quantities ...
Maximiliano Tourmente +2 more
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Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters
iScience, 2021 Summary: The golden hamster model of SARS-CoV-2 infection recapitulates key characteristics of COVID-19. In this work we examined the influence of the route of exposure, sex, and age on SARS-CoV-2 pathogenesis in hamsters. We report that delivery of SARS-
Bryan D. Griffin +28 more
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Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease
Emerging Infectious Diseases, 2012 We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein–transgenic mouse line and isolated distinct prion
Simon Nicot +5 more
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Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
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Pathology and host-pathogen interactions in a golden Syrian hamster model of Nipah virus infection
Frontiers in Veterinary ScienceNipah virus (NiV) is recognized as one of the key pathogens with pandemic potential. We have recently established a NiV hamster model, which reproduces a highly similar disease to that observed in human cases, including respiratory and neurological signs
Inés Ruedas-Torres +4 more
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Efficacy of Plant-Made Human Recombinant ACE2 against COVID-19 in a Golden Syrian Hamster Model
Viruses, 2023 Coronavirus disease 2019 (COVID-19) is a novel infectious respiratory disease caused by SARS-CoV-2. We evaluated the efficacy of a plant-based human recombinant angiotensin-converting enzyme 2 (hrACE2) and hrACE2-foldon (hrACE2-Fd) protein against COVID ...
Choon-Mee Kim +12 more
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