Results 61 to 70 of about 14,683 (231)

SV40 lymphomagenesis in Syrian golden hamsters

Virology, 2009
Simian virus 40 (SV40) isolates differ in oncogenic potential in Syrian golden hamsters following intraperitoneal inoculation. Here we describe the effect of intravenous exposure on tumor induction by SV40. Strains SVCPC (simple regulatory region) and VA45-54(2E) (complex regulatory region) were highly oncogenic following intravenous inoculation ...
Mary Jo Hamilton, Alan Herron, Janet S. Butel, Regis A. Vilchez, Vojtech Sroller, William C. Davis, Tiffany C. Heard, Adrienne L. McNees, Connie Wong   +8 more
openaire   +3 more sources

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, EarlyView.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source

Measuring Personality in Wild Small Mammals: A Review of Methods and Proposal for a Standardised Approach

Mammal Review, EarlyView.
We provide a systematic review of methodologies used to study personality in small mammals. We propose adopting ‘Standardised Experimental Design’ and ‘Behavioural Measurements’ to effectively compare results across studies and foster progress in this field.
Sara Savazza, Margaret R. Merz, Alessio Mortelliti   +2 more
wiley   +1 more source

Hibernation Impairs Odor Discrimination – Implications for Alzheimer’s Disease

Frontiers in Neuroanatomy, 2019
Reversible formation of PHF-like phosphorylated tau, an early feature of Alzheimer’s disease (AD) was previously shown to occur in torpor during hibernation in the Golden hamster (Syrian hamster, Mesocricetus auratus).
Torsten Bullmann, Emily Feneberg, Tanja Petra Kretzschmann, Vera Ogunlade, Max Holzer, Thomas Arendt   +5 more
doaj   +1 more source

Horizontal transmission of malignancy: in-vivo fusion of human lymphomas with hamster stroma produces tumors retaining human genes and lymphoid pathology. [PDF]

PLoS ONE, 2013
We report the in-vivo fusion of two Hodgkin lymphomas with golden hamster cheek pouch cells, resulting in serially-transplanted (over 5-6 years) GW-532 and GW-584 heterosynkaryon tumor cells displaying both human and hamster DNA (by FISH), lymphoma-like ...
David M Goldenberg, David V Gold, Meiyu Loo, Donglin Liu, Chien-Hsing Chang, Elaine S Jaffe   +5 more
doaj   +1 more source

Pharmacokinetics and distribution of clioquinol in golden hamsters

Journal of Pharmacy and Pharmacology, 2007
Abstract Clioquinol (5-chloro-7-iodo-8-quinolinol) is a zinc and copper chelator that can dissolve amyloid deposits and may be beneficial in Alzheimer's disease. Prion diseases are also degenerative CNS disorders characterised by amyloid deposits.
G. Bondiolotti, M. Sala, C. Pollera, M. Gervasoni, M.L. Puricelli, W. Ponti, S.R.C. Bareggi   +6 more
openaire   +3 more sources

CRISPR/Cas9‐Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production

Plant Biotechnology Journal, EarlyView.
ABSTRACT N‐Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N‐glycosylated proteins, but their use is impeded by the presence of plant‐specific N‐glycan epitopes, which raise concerns of possible immunogenicity to ...
Dolgormaa Bataa, Hiroyuki Kajiura, Reimi Lai Sang Sawada‐Choi, Yukino Yamashita, Takeshi Ishimizu, Ryo Misaki, Atsushi Takeda, Kazuhito Fujiyama   +7 more
wiley   +1 more source

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Can we study whisker movements to gain insights into the natural sensory behaviours of mammals?

The Journal of Physiology, EarlyView.
Abstract figure legend The recommended future of whisker science research is integrating findings from the laboratory with studies from other captive institutions (such as zoos, rehabilitation centres and specialist research institutes) and field observations.
Robyn A. Grant
wiley   +1 more source

Host Cell Protein Clinical Safety Risk Assessment—An Updated Industry Review

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3229-3248, November 2025.
ABSTRACT Host cell proteins (HCP) are process‐related impurities that can co‐purify with therapeutic proteins. Some HCP impurities potentially can have an impact on patient safety (immunogenicity or toxicity), efficacy, and/or product quality. It is important to reduce the levels of HCP impurities with a well‐controlled manufacturing process and to ...
Lisette Coye, Marisa A. Jones, Georgeen Gaza‐Bulseco, Carmelata Chitikila, Severine Clavier, Delphine Fougeron, Christine Grimaldi, Karen Hurkmans, Richard Hutchinson, Brenda Kellogg, Xinrong Liu, Nisha Palackal, Mahima Tank, Pascal Valax, Thomas Waerner, Fengqiang Wang, Ying Zhang, Yiwei Zhao, Sapphire Sloan, Christina Zuch de Zafra   +19 more
wiley   +1 more source