Results 71 to 80 of about 14,683 (231)

Quantifying Cytotoxicity and Cellular Uptake of Naked Gold Nanoparticles Using Total Reflection X‐Ray Fluorescence

open access: yesX-Ray Spectrometry, Volume 54, Issue 6, Page 716-724, November/December 2025.
ABSTRACT The study of the cytotoxic effects of gold nanoparticles (AuNP) is an active area of research. However, there is a lack of consistency in results with measures of cellular uptake relying on inductively coupled plasma (ICP)‐based methods, which introduce inconsistencies with sample preparation.
Natasha Hedden   +5 more
wiley   +1 more source

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto   +16 more
wiley   +1 more source

Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

open access: yesAnais da Academia Brasileira de Ciências, 2009
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a ...
Alexandre Kanashiro   +6 more
doaj   +1 more source

A New Synthetic Analogue of Protectin DX With Enhanced Therapeutic Potential Against Metabolic‐Associated Steatotic Liver Disease

open access: yesThe FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The pro‐resolving lipid mediator PDX, and a novel synthetic analogue AN‐48, were orally administered (50 ng/g) daily to hamsters fed an obesity‐inducing diet. AN‐48 prevented hepatic triglyceride accretion and reduced the expression of fatty acid synthase (FASN), responsible for de novo lipogenesis.
Frédérik Desmarais   +9 more
wiley   +1 more source

Comparison of the Fixation Effects of Six Composite Fixatives on Retinal Tissue of Golden Hamsters

open access: yesShiyan dongwu yu bijiao yixue
Objective To compare the effects of six composite fixatives on paraffin sections of golden hamster retinal tissue, and to optimize the fixation methods for retinal tissue paraffin sections of golden hamsters.
WU Haifeng   +4 more
doaj   +1 more source

Reduced-Fat Response of Lactobacillus casei subsp. casei SY13 on a Time and Dose-Dependent Model

open access: yesFrontiers in Microbiology, 2018
A reduced-fat effect of probiotics was primarily derived functionally rather than structurally, and we investigated the ultra-structural aspect of the gut mucosa in Syrian golden hamsters with high-fat diet by feeding with Lactobacillus casei subsp ...
Zhenhu Jia   +4 more
doaj   +1 more source

Pineal melatonin is a circadian time-giver for leptin rhythm in Syrian hamsters

open access: yesFrontiers in Neuroscience, 2015
Nocturnal secretion of melatonin from the pineal gland may affect central and peripheral timing, in addition to its well-known involvement in the control of seasonal physiology.
Ibtissam eChakir   +6 more
doaj   +1 more source

Genomic Mutations in SARS-CoV-2 Genome following Infection in Syrian Golden Hamster and Associated Lung Pathologies. [PDF]

open access: yesPathogens, 2023
Rudramurthy GR   +4 more
europepmc   +1 more source

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