Results 71 to 80 of about 278,673 (271)

SV40 lymphomagenesis in Syrian golden hamsters

Virology, 2009
Simian virus 40 (SV40) isolates differ in oncogenic potential in Syrian golden hamsters following intraperitoneal inoculation. Here we describe the effect of intravenous exposure on tumor induction by SV40. Strains SVCPC (simple regulatory region) and VA45-54(2E) (complex regulatory region) were highly oncogenic following intravenous inoculation ...
Mary Jo Hamilton, Alan Herron, Janet S. Butel, Regis A. Vilchez, Vojtech Sroller, William C. Davis, Tiffany C. Heard, Adrienne L. McNees, Connie Wong   +8 more
openaire   +3 more sources

A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

ELECTROPHORESIS, EarlyView.
ABSTRACT This review provides an in‐depth exploration of capillary electrophoresis–mass spectrometry (CE–MS) in biomolecular research from 2020 to 2024. CE–MS emerges as a versatile and powerful tool due to its numerous advantages, facilitating the analysis of various biomolecules, including proteins, peptides, oligonucleotides, and other metabolites ...
Laura Pont, María Vergara‐Barberán, Enrique Javier Carrasco‐Correa   +2 more
wiley   +1 more source

Horizontal transmission of malignancy: in-vivo fusion of human lymphomas with hamster stroma produces tumors retaining human genes and lymphoid pathology. [PDF]

PLoS ONE, 2013
We report the in-vivo fusion of two Hodgkin lymphomas with golden hamster cheek pouch cells, resulting in serially-transplanted (over 5-6 years) GW-532 and GW-584 heterosynkaryon tumor cells displaying both human and hamster DNA (by FISH), lymphoma-like ...
David M Goldenberg, David V Gold, Meiyu Loo, Donglin Liu, Chien-Hsing Chang, Elaine S Jaffe   +5 more
doaj   +1 more source

Phospholipid methylation increases during capacitation of golden hamster sperm in vitro.

Biology of Reproduction, 1983
The present report describes in vitro experiments with golden hamster sperm designed to determine whether there is any relationship between sperm phospholipid methylation and capacitation and/or the acrosome reaction.
M. Llanos, S. Meizel
semanticscholar   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting

Nature Communications, 2023
In vitro, ACE2 translocates to the nucleus to induce SARS-CoV-2 replication. Here, using digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters, we show that a specific and selective peptide inhibitor of nuclear ACE2 ...
Wen Juan Tu, Michelle Melino, Jenny Dunn, Robert D. McCuaig, Helle Bielefeldt-Ohmann, Sofiya Tsimbalyuk, Jade K. Forwood, Taniya Ahuja, John Vandermeide, Xiao Tan, Minh Tran, Quan Nguyen, Liang Zhang, Andy Nam, Liuliu Pan, Yan Liang, Corey Smith, Katie Lineburg, Tam H. Nguyen, Julian D. J. Sng, Zhen Wei Marcus Tong, Keng Yih Chew, Kirsty R. Short, Roger Le Grand, Nabila Seddiki, Sudha Rao   +25 more
doaj   +1 more source

Pharmacokinetics and distribution of clioquinol in golden hamsters

Journal of Pharmacy and Pharmacology, 2007
Abstract Clioquinol (5-chloro-7-iodo-8-quinolinol) is a zinc and copper chelator that can dissolve amyloid deposits and may be beneficial in Alzheimer's disease. Prion diseases are also degenerative CNS disorders characterised by amyloid deposits.
G. Bondiolotti, M. Sala, C. Pollera, M. Gervasoni, M.L. Puricelli, W. Ponti, S.R.C. Bareggi   +6 more
openaire   +3 more sources

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

Hibernation Impairs Odor Discrimination – Implications for Alzheimer’s Disease

Frontiers in Neuroanatomy, 2019
Reversible formation of PHF-like phosphorylated tau, an early feature of Alzheimer’s disease (AD) was previously shown to occur in torpor during hibernation in the Golden hamster (Syrian hamster, Mesocricetus auratus).
Torsten Bullmann, Emily Feneberg, Tanja Petra Kretzschmann, Vera Ogunlade, Max Holzer, Thomas Arendt   +5 more
doaj   +1 more source

Do Gadolinium‐Based Contrasts Represent a High Risk for Genotoxicity in Mammalian Cells? A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT The scientific rationale for this review stems from the increasing global use of gadolinium‐based contrast agents in medical imaging and the concerns over the long‐term environmental accumulation of gadolinium waste, which may pose biological risks.
Thiago Guedes Pinto, Rogerio Aparecido Dedivits, Daniel Araki Ribeiro   +2 more
wiley   +1 more source