Results 121 to 130 of about 45,796 (273)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

PERBEDAAN LEBAR GIGI ANTERIOR RAHANG ATAS DENGAN KONSEP GOLDEN PROPORTION PADA MAHASISWA FKG UNIVERSITAS ANDALAS SUKU MINANG

, 2015
Latar Belakang : Salah satu parameter yang dapat mewakili keindahan yang ideal, yaitu konsep golden proportion. Proporsinya pada gigi dilihat dari arah depan. Lebar gigi insisivus sentral 62% lebih lebar dari lebar gigi insisivus lateral.
RIANI, HAFIZA
core  

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Suitability of red fox (Vulpes vulpes) and golden jackal (Canis aureus) as hosts of Echinococcus multilocularis based on egg production characteristics and literature data on the intestinal ecosystems of carnivores

Current Research in Parasitology and Vector-Borne Diseases
Echinococcus multilocularis is the most important food-borne parasite in Europe. Its natural definitive host is the red fox (Vulpes vulpes) while other canid species play a secondary role in the maintenance of its endemics.
Sibusiso Moloi, Tibor Halász, Ágnes Csivincsik, Gábor Nagy   +3 more
doaj   +1 more source

The Application Of Golden Proportion, Recurring Esthetic Dental Proportion, and Golden Percentage For Maxillary Anterior Teeth In A Group Of Jordanians

, 2012
AbstractBackground: Many dental equations had been created to achieve perfect shaped teeth, especially the maxillary anterior ones, which are responsible of dental esthetics. The most investigated equations were the Golden Proportion, Recurring Esthetic Dental proportion (RED), and the Golden Percentage.Aim of The Study: this study aimed to verify the ...
openaire   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Analysis of the skeletal and soft-tissue profiles pre and post orthognathic surgery in Class II and III patients and its relation with the golden proportion

, 2017
Introduction The golden proportion, represented by the mathematical ratio 1:1.618, has been investigated in Orthodontics and orthognathic surgery in order to be established as a guide to clinical success related to facial aesthetics. Objective To verify
Elen de Souza TOLENTINO (6128645), Wilton Mitsunari TAKESHITA (4647202), Mariliani Chicarelli da SILVA (6128648), Leticia Ângelo WALEWSKI (6128642)   +3 more
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

A STUDY TO ASSESS AND CORRELATE THE EXISTENCE OF GOLDEN PROPORTION BETWEEN FACE AND TEETH

, 2018
There is a universal standard for facial beauty regardless of race, age, sex, and other variables. Regardless of how attractive the teeth appear in isolation if spatially they don\u27t corelate to the rest of the facial structures, then the overall ...
Roseline Meshramkar, Lekha K P, Pratiksha Shivram, Ramesh K. Nadiger   +3 more
core   +1 more source