Results 21 to 30 of about 5,754 (246)

Imagem radiográfica da cavidade torácica de cães Golden Retriever acometidos pela distrofia muscular Radiologic images of the thoracic cavity of Golden Retriever dogs affected by muscular dystrophy

Pesquisa Veterinária Brasileira, 2009
A distrofia muscular de Duchenne (DMD) é uma doença de origem genética, cuja principal manifestação clínica é enfraquecimento e atrofia progressiva dos músculos.
Flávio R. Alves, Matheus L.T. Feitosa, André Gatti, Leandro Fadel, Silvana M. Unruh, Carlos E. Ambrósio, Franklin A. Sterman, Ana C.B.C.F. Pinto, Maria A. Miglino   +8 more
doaj   +1 more source

Sebaceous Adenoma Case in a Golden Retriever Dog

Journal of Applied Veterinary Science and Technology, 2023
Background: Sebaceous adenoma is a benign tumour originating from the skin's sebaceous glands. These tumours can arise in older and middle-aged dogs, typically on various body parts, head, and extremities.
Palagan Senopati Sewoyo, Willy Moris Nainggolan   +1 more
doaj   +1 more source

Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin‐Deficient Hearts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCardiomyopathy is a leading cause of mortality among Duchenne muscular dystrophy patients and lacks effective therapies. Phosphodiesterase type 5 is implicated in dystrophic pathology, and the phosphodiesterase type 5 inhibitor tadalafil has ...
David W. Hammers, Margaret M. Sleeper, Sean C. Forbes, Ai Shima, Glenn A. Walter, H. Lee Sweeney   +5 more
doaj   +1 more source

Características clínicas e genéticas da ictiose em cães: artigo de revisão

Medicina Veterinária, 2021
A ictiose é uma doença dermatológica cujo principal sinal clínico é a descamação generalizada da pele. Trata-se de uma doença genética rara na maior parte das raças, porém relativamente comum no Golden Retriever.
Fabiana Michelsen de Andrade, Greyce Meyer Ramos, Jaime Araujo Cobuci, Daniela Flores Fernandes   +3 more
doaj  

Hereditary Spectrin Deficiency in Golden Retriever Dogs [PDF]

Journal of Veterinary Internal Medicine, 2005
Abstract Spectrin deficiency with increased erythrocyte osmotic fragility (OF) is a hallmark of hereditary spherocytosis, which is the most common congenital hemolytic anemia in humans of northern European ancestry. A radioimmunoassay revealed that erythrocyte spectrin concentration was 50–65% of normal in 5 adult Golden Retriever ...
Slappendel, R.J., van Zwieten, R., van Leeuwen, M., Schneijdenberg, C.T.W.M.   +3 more
openaire   +3 more sources

Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression

Veterinární Medicína, 2011
Progressive rod-cone degeneration (PRCD) is a late onset autosomal photoreceptor degeneration found in canines. PRCD in canines is homologous to one form of retinitis pigmentosa (RP) found in humans and displays phenotypic similarity as well as having ...
J. Dostal, A. Hrdlicova, P. Horak
doaj   +1 more source

Canal flare index evaluation for different dog breeds [PDF]

Ciência Rural
: This study determined the canal flare index (CFI) of four dog breeds using two distinct femoral regions as a reference. Thirty-five radiographs of the hip joints of Golden Retrievers (GRG), German Shepherds (GSG), Labrador Retrievers (LRG), and ...
Paula Regina Silva Gomide, Luís Renato Veríssimo de Souza, Caroline Ribeiro de Andrade, Rafael Manzini Dreibi, Bianca Paola Santarosa, Bruno Watanabe Minto   +5 more
doaj   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Utrophin, MHC and M1/M2 macrophages in GRMD dogs

Ciência Animal Brasileira, 2020
Muscular dystrophies are hereditary diseases that lead to progressive degeneration of the skeletal musculature. Golden Retriever dogs are used as animal models because they show a hereditary muscle disease similar to muscular dystrophy in humans.
Gabriela Noronha de Toledo, Julieta Rodini Engracia de Moraes   +1 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source