Results 61 to 70 of about 775,303 (293)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The multi-staged “golden zones” of hydrocarbon exploration in superimposed petroliferous basins of onshore China and its significance

open access: yesPetroleum Exploration and Development, 2015
The hydrocarbon generation model proposed by Tissot et al. points out the temperature and depth of “liquid HC window”, which has become a “golden zone” for hydrocarbon exploration.
Wenzhi ZHAO   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

ISSUES OF VERSE THEORY: AESTHETIC CATEGORIES AND THE POETIC TEXT [PDF]

open access: yesRespectus Philologicus, 2014
This article discusses issues of verse theory as it relates to the stanza as a structural unit of a poetic text. The basic aesthetic categories (limits, harmony, grace, and beauty) are considered from the position of mathematical aesthetics, and a ...
Oleg Grinbaum
doaj  

Geographic Information System Technology Combined with Back Propagation Neural Network in Groundwater Quality Monitoring

open access: yesISPRS International Journal of Geo-Information, 2020
This study was conducted to explore the distribution and changes of groundwater resources in the research area, and to promote the application of geographic information system (GIS) technology and its deep learning methods in chemical type distribution ...
Jing Sun, Genhou Wang
doaj   +1 more source

Dissolving cusp forms: Higher order Fermi's Golden Rules

open access: yes, 2010
For a hyperbolic surface embedded eigenvalues of the Laplace operator are unstable and tend to become resonances. A sufficient dissolving condition was identified by Phillips-Sarnak and is elegantly expressed in Fermi's Golden Rule. We prove formulas for
Petridis, Yiannis N., Risager, Morten S.
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Performance of Turbo-Codes with Some Proposed Interleaver Schemes

open access: yesAl-Khawarizmi Engineering Journal, 2006
This paper describes a number of new interleaving strategies based on the golden section. The new interleavers are called golden relative prime interleavers, golden interleavers, and dithered golden interleavers. The latter two approaches involve sorting
Ahmed S. Hadi
doaj  

A parametric analysis of the “digitally-derived geometric design” of the façade of the Macau Holy house of Mercy

open access: yesJournal of Asian Architecture and Building Engineering, 2022
The Macau Holy House of Mercy was built in 1569 and rebuilt in the 18th century. Located in the historic center of Macao, the Macau Holy House of Mercy is included on the World Heritage List of UNESCO.With the Macau Holy House of Mercy, especially the ...
Jian Tang
doaj   +1 more source

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