Results 101 to 110 of about 37,981 (219)

Nivolumab plus ipilimumab versus lenvatinib or sorafenib as first‐line treatment for unresectable hepatocellular carcinoma: A cost‐effectiveness analysis

open access: yesCancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Nivolumab plus ipilimumab has shown survival benefits as first‐line treatment for unresectable hepatocellular carcinoma (HCC) but their high cost raises concerns about value. This study assessed the cost‐effectiveness of nivolumab plus ipilimumab compared with lenvatinib or sorafenib from a United States (US) health care payer ...
Jiefeng Luo   +8 more
wiley   +1 more source

Longitudinal Analysis of Manually and Automatically Classified Circulating Tumor Biomarkers and their Prediction of Survival in Metastatic Colorectal Cancer

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 403-413, February 2026.
Circulating tumor cells (CTCs) and tumor‐derived extracellular vesicles (tdEVs) are promising biomarkers for predicting survival and informing treatment decisions in metastatic colorectal cancer (mCRC); yet their clinical application remains limited. In this study, we analyzed CellSearch image archives from 446 patients with mCRC treated in the CAIRO2 ...
Maddalena Centanni   +6 more
wiley   +1 more source

Linking period and cohort life-expectancy linear increases in Gompertz proportional hazards models [PDF]

open access: yes
In a Gompertz mortality model with constant yearly improvements at all ages, linear increases in period life expectancy correspond to linear increases in the respective cohort life expectancy.
Adam Lenart, Trifon I. Missov
core  

Valuation and hedging of the ruin-contingent life annuity (RCLA) [PDF]

open access: yes, 2012
This paper analyzes a novel type of mortality contingent-claim called a ruin-contingent life annuity (RCLA). This product fuses together a path-dependent equity put option with a "personal longevity" call option. The annuitant's (i.e.
Huang, Huaxiong   +2 more
core   +1 more source

Cholecysto-Colonic Fistula: A Rare Case [PDF]

open access: yesLibyan Journal of Medicine, 2007
A 72 year old female was referred by her general practitioner (GP) on the urgent two- week waiting list with a history of weight loss, diarrhoea and a mass on the right upper quadrant with a possible underlying malignancy.
Henry Gompertz, Abdulmajid Ahmed Ali
doaj  

Population Physiologically‐Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions. Ethical concerns often limit clinical pharmacology studies that have no direct therapeutic benefit in children, highlighting the value of PBPK model predictions.
Yumi Cleary   +4 more
wiley   +1 more source

Body Mass Records of Zoo‐Managed Rhinoceros (Ceratotherium simum, Diceros bicornis, Rhinoceros unicornis) as Compared to Field Data of Free‐Ranging Specimens

open access: yesZoo Biology, Volume 45, Issue 1, Page 74-83, January/February 2026.
Female white rhinos in zoos systematically exceed the body mass range for free‐ranging specimens; this is not the case in black rhinos. ABSTRACT The body mass of zoo animals may differ from those in wild populations due to the different environmental and dietary conditions being offered under human‐managed care.
Elisa Garand   +7 more
wiley   +1 more source

Contribution Factors on Long- term and Short- term Survival of Thalassemia Major Patients

open access: yesJournal of Biostatistics and Epidemiology, 2021
Background: Thalassemia major is an important health problem in Mediterranean countries, placing a tremendous emotional, psychological, and economic burden.
Sevda Riahifar   +5 more
doaj  

Rancangan D-Optimal Model Gompertz dengan Maple

open access: yesMedia Statistika, 2017
Gompertz model is used in many areas including biological growth studies, animal and husbandry, chemistry, and agricultural. Locally D-optimal designs for Gompertz models with three parameters is investigated.
Tatik Widiharih, Budi Warsito
doaj   +1 more source

Associations Between Polybrominated Diphenyl Ethers and Biological Aging in NHANES 2005–2010 and 2015–2016

open access: yesGeoHealth, Volume 10, Issue 2, February 2026.
Abstract The associations of polybrominated diphenyl ethers (PBDEs) with biological aging are unclear. This study explores the possible relationship between PBDEs and accelerated aging. Cross‐sectional data from 6,091 subjects of the National Health and Nutrition Examination Survey (NHANES) 2005–2010 and 2015–2016 are analyzed.
Yan Chen   +3 more
wiley   +1 more source

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