Results 101 to 110 of about 37,981 (219)
Abstract Background Nivolumab plus ipilimumab has shown survival benefits as first‐line treatment for unresectable hepatocellular carcinoma (HCC) but their high cost raises concerns about value. This study assessed the cost‐effectiveness of nivolumab plus ipilimumab compared with lenvatinib or sorafenib from a United States (US) health care payer ...
Jiefeng Luo +8 more
wiley +1 more source
Circulating tumor cells (CTCs) and tumor‐derived extracellular vesicles (tdEVs) are promising biomarkers for predicting survival and informing treatment decisions in metastatic colorectal cancer (mCRC); yet their clinical application remains limited. In this study, we analyzed CellSearch image archives from 446 patients with mCRC treated in the CAIRO2 ...
Maddalena Centanni +6 more
wiley +1 more source
Linking period and cohort life-expectancy linear increases in Gompertz proportional hazards models [PDF]
In a Gompertz mortality model with constant yearly improvements at all ages, linear increases in period life expectancy correspond to linear increases in the respective cohort life expectancy.
Adam Lenart, Trifon I. Missov
core
Valuation and hedging of the ruin-contingent life annuity (RCLA) [PDF]
This paper analyzes a novel type of mortality contingent-claim called a ruin-contingent life annuity (RCLA). This product fuses together a path-dependent equity put option with a "personal longevity" call option. The annuitant's (i.e.
Huang, Huaxiong +2 more
core +1 more source
Cholecysto-Colonic Fistula: A Rare Case [PDF]
A 72 year old female was referred by her general practitioner (GP) on the urgent two- week waiting list with a history of weight loss, diarrhoea and a mass on the right upper quadrant with a possible underlying malignancy.
Henry Gompertz, Abdulmajid Ahmed Ali
doaj
ABSTRACT Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions. Ethical concerns often limit clinical pharmacology studies that have no direct therapeutic benefit in children, highlighting the value of PBPK model predictions.
Yumi Cleary +4 more
wiley +1 more source
Female white rhinos in zoos systematically exceed the body mass range for free‐ranging specimens; this is not the case in black rhinos. ABSTRACT The body mass of zoo animals may differ from those in wild populations due to the different environmental and dietary conditions being offered under human‐managed care.
Elisa Garand +7 more
wiley +1 more source
Contribution Factors on Long- term and Short- term Survival of Thalassemia Major Patients
Background: Thalassemia major is an important health problem in Mediterranean countries, placing a tremendous emotional, psychological, and economic burden.
Sevda Riahifar +5 more
doaj
Rancangan D-Optimal Model Gompertz dengan Maple
Gompertz model is used in many areas including biological growth studies, animal and husbandry, chemistry, and agricultural. Locally D-optimal designs for Gompertz models with three parameters is investigated.
Tatik Widiharih, Budi Warsito
doaj +1 more source
Abstract The associations of polybrominated diphenyl ethers (PBDEs) with biological aging are unclear. This study explores the possible relationship between PBDEs and accelerated aging. Cross‐sectional data from 6,091 subjects of the National Health and Nutrition Examination Survey (NHANES) 2005–2010 and 2015–2016 are analyzed.
Yan Chen +3 more
wiley +1 more source

