Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis. [PDF]
, 2006 Atrazine is a potent endocrine disruptor that both chemically castrates and feminizes male amphibians. It depletes androgens in adult frogs and reduces androgen-dependent growth of the larynx in developing male larvae.
Collins, Atif +8 more
core +2 more sources
Latin American Journal of Aquatic Research, 2015 A detailed study of gametes development and characterization of plasma sex steroid hormones during the maturation cycle was performed for the first time in the southern hake (Merluccius australis).
Manuel Alvarado +3 more
doaj +1 more source
New directions for the treatment of adrenal insufficiency [PDF]
, 2015 The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB)
Allen +69 more
core +2 more sources
Sexually Dimorphic Roles of Steroid Hormone Receptor Signaling in Gonadal Tumorigenesis [PDF]
Molecular Endocrinology, 2003 Sex steroids control cellular phenotypes by binding to receptor proteins that in turn regulate downstream gene expression. They are important tropic factors in hormonally responsive tissues and have been implicated in the pathogenesis of both benign proliferations and malignancies at some of these sites.
Kathleen H, Burns +6 more
openaire +2 more sources
Sexual dimorphism in immune function: The role of sex steroid hormones
SHS Web of Conferences, 2018 There is evidence of the relation of sex steroid hormones and sexual dimorphism in immune system response to infectious diseases. The aim of this review was to identify the role of sex hormones in immune function and sexual dimorphism of immune reactions.
Mihailova Anna, Krams Indrikis
doaj +1 more source
Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis
Cells, 2023 Multiple sclerosis (MS) is an autoimmune disease affecting the CNS and occurring far more prevalently in women than in men. In both MS and its animal models, sex hormones play important immunomodulatory roles.
Ana Milosevic +6 more
doaj +1 more source
The endocannabinoid system and spermatogenesis
Frontiers in Endocrinology, 2013 Spermatogenesis is a complex process in which male germ cells undergo a mitotic phase followed by meiosis and by a morphogenetic process to form mature spermatozoa.
Paola eGrimaldi +2 more
doaj +1 more source
Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]
, 2012 Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S. +3 more
core +2 more sources
Relations of environmental contaminants, algal toxins, and diet with the reproductive success of American alligators on Florida Lakes [PDF]
, 2001 (113 page ...
Arnold, Beverly S. +3 more
core
The "backdoor pathway" of androgen synthesis in human male sexual development. [PDF]
, 2019 Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a
Auchus, Richard J, Miller, Walter L
core +2 more sources