New directions for the treatment of adrenal insufficiency [PDF]
The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB)
Allen+69 more
core +1 more source
Immunomodulatory Actions of Gonadal Steroids May Be Mediated by Gonadotropin-Releasing Hormone [PDF]
Estrogens are considered to be immunostimulatory, whereas androgens are considered to be immunosuppressive. We hypothesized that the divergent actions of gonadal steroids on the immune system may be mediated indirectly, via their potent divergent feedback effects on the hypothalamic hormone GnRH, which is itself immunostimulatory.
Jill D. Jacobson, Mansoor A. Ansari
openaire +3 more sources
Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later‐life in vivo markers of β‐amyloid (Aβ) and tau deposition in clinically healthy older men. Methods This time‐
Rachel F. Buckley+16 more
wiley +1 more source
Post-menopausal ovarian fibroma associated with steroid hormone synthesis: A case report
Objective: Ovarian fibromas are benign, sex cord-stromal tumors occurring in both peri- and post-menopausal women. Generally, these tumors are non-functional and do not produce hormones.
Naomi Sato+5 more
doaj
Automating LC-MS/MS mass chromatogram quantification. Wavelet transform based peak detection and automated estimation of peak boundaries and signal-to-noise ratio using signal processing methods [PDF]
While there are many different methods for peak detection, no automatic methods for marking peak boundaries to calculate area under the curve (AUC) and signal-to-noise ratio (SNR) estimation exist. An algorithm for the automation of liquid chromatography tandem mass spectrometry (LC-MS/MS) mass chromatogram quantification was developed and validated ...
arxiv
Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]
Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S.+3 more
core +2 more sources
Effect of gonadal steroid hormones on formalin‐induced temporomandibular joint inflammation [PDF]
AbstractWe have recently demonstrated that gonadal steroid hormones decrease formalin‐induced temporomandibular joint nociception in rats. Given that the attenuation of inflammation is a potential mechanism underlying this antinociceptive effect, we evaluated the effect of gonadal steroid hormones on formalin‐induced temporomandibular joint ...
Adriana Pelegrini-da-Silva+6 more
openaire +3 more sources
Pharmacokinetics of Two Formulations of Altrenogest Administered to Mares
Pharmacokinetics of altrenogest in mares to determine expected concentrations of plasma altrenogest associated with oral and intramuscular administration. Quantification of altrenogest in mares is of increasing importance with prohibited formulations and restrictions on administration.
Jaymie Loy+5 more
wiley +1 more source
The Role of Steroid Hormones on the Modulation of Neuroinflammation by Dietary Interventions
Steroid hormones, such as sex hormones and glucocorticoids, have been demonstrated to play a role in different cellular processes in the central nervous system, ranging from neurodevelopment to neurodegeneration.
Andrea Rodrigues Vasconcelos+4 more
doaj +1 more source
Endocrinology of Transgender Medicine [PDF]
Gender-affirming treatment of transgender people requires a multidisciplinary approach in which endocrinologists play a crucial role. The aim of this paper is to review recent data on hormonal treatment of this population and its effect on physical ...
Arcelus, Jon+4 more
core +1 more source