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Gonadotropin-releasing hormone deficiency in men: Diagnosis and treatment with exogenous gonadotropin-releasing hormone [PDF]
American Journal of Obstetrics and Gynecology, 1990 Idiopathic hypogonadotropic hypogonadism in men is the result of absent or abnormal secretion of gonadotropin-releasing hormone, which prevents pubertal development. Isolated gonadotropin-releasing hormone deficiency is clinically and neuroendocrinologically heterogeneous, largely because of variation in the degree of gonadotropin-releasing hormone ...
William F. Crowley, R W Whitcomb
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Gonadotropin-Releasing Hormone
Annual Review of Medicine, 1975The existence of a hypothalamic gonadotropin-releasing hormone long suspected from indirect evidence (1) has now been conclusively proven. In 1971, the primary structure of porcine (2) and subsequently ovine (3) luteinizing hormone-releasing hormone or factor (LRH or LRF) was determined to be the decapeptide pGlu-His Trp-Ser-Tyr-Gly-Leu-Arg-pro-Gly ...
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Conformation of gonadotropin releasing hormone
Biochemistry, 1976The conformation of the gonadotropin releasing hormone (Gn-RH), whose primary sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2, and of several of its structural analogues has been studied by circular dichroism, optical rotatory dispersion, and fluorescence spectroscopy.
Susan Mabrey, Irving M. Klotz
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GONADOTROPIN-RELEASING HORMONE AND ITS ANALOGS
Annual Review of Medicine, 1991▪ Abstract GnRH and its analogues have led to exciting new avenues of therapy in virtually every subspecialty of internal medicine as well as in gynecology, pediatrics, and urology. Since their discovery in 1971, it has been demonstrated that GnRH and its analogues enable medical professionals to influence the hypothalamic-pituitary-gonadal axis in ...
Jane F. Desforges +2 more
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Clinical applications of gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs
Fertility and Sterility, 1983Investigations have proved the clinical importance of hypothalmic gonadotropin-releasing hormone (GnRH) and its agonistic and antagonistic analogs. A pulsatile pattern of stimulation of specific receptors in the anterior pituitary gonadotrope has been shown to activate pituitary-gonadal function; continuous administration inhibits it.
Samuel S.C. Yen, Edward E. Wallach
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Model of gonadotropin-releasing hormone and gonadotropin-releasing hormone complex
Sexuality and Disability, 2006Gonadotropin-releasing hormone (GnRH) neurons provide the primary driving force upon the other levels of the reproductive axis. Similar to other hormone, GnRH receptor can be identified. The main intracellular pathway activated by stimulation of GnRH receptors (GnRHRs) is related to Gq protein which induces a cytoplasmic metabolic cascade.
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Molecular Biology of Gonadotropin-Releasing Hormone and the Gonadotropin-Releasing Hormone Receptor [PDF]
, 1999 Gonadotropin-releasing hormone (GnRH) is a hypothalamic decapeptide that plays a fundamental role in the reproductive events of all mammalian species. GnRH was first isolated in the early 1970s by Schally (1) and Guillemin (2). Since that time there has been an explosion of knowledge regarding the physiology and genetic structure of GnRH and its ...
Barry B. Bercu, Dorothy I. Shulman
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Gonadotropin-Releasing Hormone
2002Publisher Summary This chapter focuses on the development and anatomy of gonadotropin-releasing hormone (GnRH) neuronal system; some of the factors and mechanisms that regulate GnRH neurons; and the localization, regulation, and functional aspects of GnRH receptors in the brain.
Lothar Jennes, P. Michael Conn
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General and Comparative Endocrinology, 1989
Two forms of immunoreactive gonadotropin-releasing hormone (GnRH) were detected in extracts of brain-pituitary tissue from the African catfish, Clarias gariepinus. Catfish I GnRH eluted first from reverse-phase HPLC and was present in larger amounts compared with catfish II GnRH.
Sherwood, Nancy M. +2 more
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Two forms of immunoreactive gonadotropin-releasing hormone (GnRH) were detected in extracts of brain-pituitary tissue from the African catfish, Clarias gariepinus. Catfish I GnRH eluted first from reverse-phase HPLC and was present in larger amounts compared with catfish II GnRH.
Sherwood, Nancy M. +2 more
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Immunobiology of gonadotropin-releasing hormone
Journal of Steroid Biochemistry, 1985This article will review methods successful in inducing antibody responses against gonadotropin releasing hormone without the use of Freund's complete adjuvant (FCA), the characteristics of the antibodies produced, and will describe the dominant antigenic determinant(s) of the decapeptide and the use of monoclonal antibodies for suppression of estrus ...
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