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BJU International, 2018
To compare the metabolic changes between men with advanced prostate cancer commenced on a gonadotropin‐releasing hormone (GnRH) agonist and those treated with orchiectomy.
P. Østergren +5 more
semanticscholar +1 more source
To compare the metabolic changes between men with advanced prostate cancer commenced on a gonadotropin‐releasing hormone (GnRH) agonist and those treated with orchiectomy.
P. Østergren +5 more
semanticscholar +1 more source
Gonadotropin-Releasing Hormone
Annual Review of Medicine, 1975The existence of a hypothalamic gonadotropin-releasing hormone long suspected from indirect evidence (1) has now been conclusively proven. In 1971, the primary structure of porcine (2) and subsequently ovine (3) luteinizing hormone-releasing hormone or factor (LRH or LRF) was determined to be the decapeptide pGlu-His Trp-Ser-Tyr-Gly-Leu-Arg-pro-Gly ...
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Gonadotropin-Releasing Hormone
2002Publisher Summary This chapter focuses on the development and anatomy of gonadotropin-releasing hormone (GnRH) neuronal system; some of the factors and mechanisms that regulate GnRH neurons; and the localization, regulation, and functional aspects of GnRH receptors in the brain.
Lothar Jennes, P. Michael Conn
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Gonadotropin-Releasing Hormone Neuronal Migration
Seminars in Reproductive Medicine, 2007Neurons that synthesize and secrete the decapeptide gonadotropin-releasing hormone-1 (GnRH-1) to control the reproductive axis originate in the olfactory placode/vomeronasal organ of the olfactory system of mammals and migrate along vomeronasal nerves to the cribriform plate, which marks the boundary between the peripheral olfactory system and the ...
Schwarting, Gerald A. +2 more
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Superactive Gonadotropin-Releasing Hormone Agonists
Annual Review of Medicine, 1983Superactive GnRH agonists represent a new class of pharmacologic agents that inhibit reproductive function in both men and women when administered chronically. These hormonal drugs are being tested extensively as both male and female contraceptive agents, as a treatment for prostate cancer, and as a new treatment for idiopathic precocious puberty ...
R S, Swerdloff, D, Heber
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Emerging gonadotropin-releasing hormone agonists
Expert Opinion on Emerging Drugs, 2011Gonadotropin-releasing hormone agonist analogs (GnRHa) are peptides that mimic the action of gonadotropin-releasing hormone (GnRH) and are used to suppress subsequent sex steroid production. Although the analogs are a rather defined group of drugs, there have been developments in the past decades and there is still ample room for improvement.
Daniel Alexander, Beyer +6 more
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Conformation of gonadotropin releasing hormone
Biochemistry, 1976The conformation of the gonadotropin releasing hormone (Gn-RH), whose primary sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2, and of several of its structural analogues has been studied by circular dichroism, optical rotatory dispersion, and fluorescence spectroscopy.
S, Mabrey, I M, Klotz
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Evolution of gonadotropin-releasing hormones
Trends in Endocrinology & Metabolism, 1992GnRH was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, multiple molecular forms of the peptide have evolved, which have been coopted for a variety of regulatory functions: as a neurotransmitter in the central and sympathetic ...
J A, King, R P, Millar
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Clinical applications of gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs.
Fertility and sterility, 1983Investigations have proved the clinical importance of hypothalmic gonadotropin-releasing hormone (GnRH) and its agonistic and antagonistic analogs. A pulsatile pattern of stimulation of specific receptors in the anterior pituitary gonadotrope has been shown to activate pituitary-gonadal function; continuous administration inhibits it.
Edward E. Wallach, Samuel S.C. Yen
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Gonadotropin-releasing hormone analog therapeutics
Minerva Ginecologica, 2018Dysregulation at any level of the hypothalamic-pituitary-gonadal (HPG) axis results in, or aggravates, a number of hormone-dependent diseases such as delayed or precocious puberty, infertility, prostatic and ovarian cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, endometriosis, uterine fibroids, lean body mass, as well as metabolism ...
Claire L, Newton +2 more
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