Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]
, 2016 Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A +11 more
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The use of GnRH analogs in preserving ovarian function during chemotherapy
Middle East Fertility Society Journal, 2021 Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving ...
Omar M. Odeh +3 more
doaj +1 more source
Choosing trigger of ovulation for optimization of in vitro fertilization programs (literature review) [PDF]
Гинекология, 2016 This review presents recent data on the impact of different triggers on the clinical and embryological indicators of the effectiveness of assisted reproductive technology in patients with normal and excessive ovarian response to superovulation ...
S M Eapen +4 more
doaj
Gonadotropin-releasing hormone antagonists [PDF]
Current Opinion in Pharmacology, 2003 Hypothalamic gonadotropin-releasing hormone (GnRH) is a decapeptide that stimulates pituitary synthesis and secretion of gonadotropins and, therefore, gonadal hormones. GnRH antagonists, of which thousands have been formulated, inhibit the hormone from binding to its receptor, inducing a pharmacological hypophysectomy.
openaire +2 more sources
Effect of luteal phase support gonadotropin-releasing hormone agonist on the endometrial receptivity and outcomes of in vitro fertilization programs [PDF]
Гинекология, 2016 Patients with tubal infertility in implantation window period show impaired endometrial receptivity with low implantation potention that is characterized by decrease in mature pinopodes level on endometrium, decreased expression of leukemia inhibitory ...
E M Savelyeva +3 more
doaj
Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]
, 2012 Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Bloom, Stephen R. +11 more
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Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life [PDF]
, 1987 To determine the origin of estrogens in infant blood, we measured estrone (E1) and estradiol (E2) in the gonads of 50 girls and 64 boys who died suddenly between birth and 2 yr of age as well as in the adrenals of 18 of these infant girls and 16 of the ...
Bidlingmaier, F. +4 more
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pS6K1 as an efficacy marker of GnRH agonist with premenopausal breast cancer
Endocrine Connections, 2019 Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor-positive breast cancer. Adipocytes are one source of estradiol in patients with breast cancer. Recent studies have shown that phosphorylated ribosomal protein S6 kinase-1 plays
Chan Sub Park +8 more
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Hormonal regulation of female reproduction [PDF]
, 2012 Reproduction is an event that requires the coordination of peripheral organs with the nervous system to ensure that the internal and external environments are optimal for successful procreation of the species.
Bentley, G. E. +6 more
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Protein and mRNA expression of gonadotropin-releasing hormone receptor in yaks during estrus
Revista Brasileira de Zootecnia, 2018 To demonstrate the role of gonadotropin-releasing hormone (GnRH) in yaks (Bos grunniens), we characterized the expression of gonadotropin-releasing hormone receptor (GnRHR) mRNA and protein.
Sheng-dong Huo +5 more
doaj +1 more source