Results 51 to 60 of about 565,388 (253)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor [PDF]

, 2008
Includes abstract.Includes bibliographical references (p. 179-202).The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins.
Coetsee, Marla Catherine
core   +1 more source

Protein and mRNA expression of gonadotropin-releasing hormone receptor in yaks during estrus

Revista Brasileira de Zootecnia, 2018
To demonstrate the role of gonadotropin-releasing hormone (GnRH) in yaks (Bos grunniens), we characterized the expression of gonadotropin-releasing hormone receptor (GnRHR) mRNA and protein.
Sheng-dong Huo, Tao-jie Zhang, Ayimuguli Abudureyimu, Jun-lin Liu, Guo-hua Zhang, Zhong-ren Ma   +5 more
doaj   +1 more source

Gonadotropin-releasing hormone antagonists [PDF]

Current Opinion in Pharmacology, 2003
Hypothalamic gonadotropin-releasing hormone (GnRH) is a decapeptide that stimulates pituitary synthesis and secretion of gonadotropins and, therefore, gonadal hormones. GnRH antagonists, of which thousands have been formulated, inhibit the hormone from binding to its receptor, inducing a pharmacological hypophysectomy.
openaire   +2 more sources

Substance p immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. [PDF]

, 2013
Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion.
Herczeg, László, László Herczeg, Hrabovszky, E, Bloom, SR, Borsay, Beáta Á., Kálmán Rácz, Hrabovszky, Erik, Borsay, BA, Borsay Beáta Á., Ghatei Mohammad A., Liposits Zsolt, Rácz Kálmán, Ciofi Philippe, Ciofi, Philippe, Beáta Á Borsay, Dhillo, WS, Liposits, Z, Herczeg László, Mohammad A Ghatei, Racz, K, Hrabovszky Erik, Dhillo, Waljit S., Ciofi, P, Philippe Ciofi, Ghatei, MA, Liposits, Zsolt, Erik Hrabovszky, Bloom Stephen R., Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Waljit S Dhillo, Herczeg, L, Dhillo Waljit S., Stephen R Bloom, Zsolt Liposits   +35 more
core   +1 more source

A delay differential equation mathematical model for the control of the hormonal system of the hypothalamus, the pituitary and the testis in man [PDF]

, 2009
In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves
Greenhalgh, David, Khan, Qamar J. A., Sultan Qaboos University, Oman (Funder)   +2 more
core   +4 more sources

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Profile of Relugolix in the Management of Advanced Hormone-Sensitive Prostate Cancer: Design, Development, and Place in Therapy

Drug Design, Development and Therapy, 2023
Tomoyuki Tatenuma,1,2 Hiroshi Miyamoto1,3 1Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA; 2Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan ...
Tatenuma T, Miyamoto H
doaj  

Investigation the polymorphism of gonadotropin releasing hormone receptor gene in Iraq sheep

The Iraqi Journal of Veterinary Medicine, 2017
In the present study, the investigation includes the estrus activity after synchronization of estrus by using 20 mg impregnated sponges with Medroxy Progesterone Acetate for 12 days with 400 IU I/M injection of pregnant mare serum gonadotropin 24 hrs ...
Hayder Abdul-Kareem Hasan AL-Mutar
doaj   +1 more source

Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2019
Purpose The standard method used to diagnose central precocious puberty (CPP) is the gonadotropin releasing hormone stimulation test (GnRHST). However, this test is inconvenient for children because it is time-consuming and requires multiple samples ...
Dong-Min Lee, In-Hyuk Chung
doaj   +1 more source