Results 71 to 80 of about 224,439 (383)
Advanced Science, EarlyView.ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma +18 more
wiley +1 more source
F&S Reports, 2023 Gonadotropin-releasing hormone (GnRH) is central to the control of the entire hypothalamic-pituitary-gonadal axis. Manipulation of GnRH, in turn, regulates pituitary response and ovarian hormone production.
Farrah L. Saleh, M.D. +1 more
doaj
Estrous behavior in dairy cows: identification of underlying mechanisms and gene functions [PDF]
, 2010 Selection in dairy cattle for a higher milk yield has coincided with declined fertility. One of the factors is reduced expression of estrous behavior. Changes in systems that regulate the estrous behavior could be manifested by altered gene expression ...
Beerda, B. +3 more
core +2 more sources
Advanced Science, EarlyView.The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang +11 more
wiley +1 more source
Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses [PDF]
PLoS ONE 11(4):e0152446 (2016), 2015 Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while the role of $\delta$ cells is less clear.
arxiv +1 more source
Microtranscriptome regulation by gonadotropin-releasing hormone [PDF]
Molecular and Cellular Endocrinology, 2009 Gonadotropin-releasing hormone (GnRH) regulates biosynthesis in the pituitary gonadotrope via a complex signaling and gene network. Small non-coding microRNAs (miRNA) can play important roles in gene expression. We investigated the microtranscriptome in the mouse L?T2 gonadotrope cell line using microarray, single molecule coincidence detection assays,
Tony Yuen +3 more
openaire +3 more sources
Advanced Science, EarlyView.LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang +5 more
wiley +1 more source
BMC Research Notes, 2018 Objectives In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.
Richard Fjellaksel +7 more
doaj +1 more source
Orlicz hormonic Blaschke addition [PDF]
arXiv, 2021 Recently, Gardner, Hug and Weil have introduced the Orlicz-Brunn-Minkowski theory: a general framework, additions, and inequalities. Following this, in the paper we consider Orlicz dual Brunn-Minkowski theory. We introduce Orlicz hormonic Blaschke addition which is an extension of the Lp hormonic Blaschke addition and L p radial Minkowski addition ...
arxiv
A Splice‐Region Variant Causes an Atypical Presentation of GNAS Inactivation Disorder
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Pathogenic variants in GNAS can cause a wide range of diseases including pseudohypoparathyroidism, pseudopseudohypoparathyroidism, McCune‐Albright syndrome, among others. The specific phenotypic features that may be seen are influenced by the variant type and location in the gene, whether it causes loss or gain of function, and whether it is ...
Brandon S. Stone +11 more
wiley +1 more source