Results 51 to 60 of about 68,932 (288)

Effekte des LHRH-Agonisten Triptorelin auf die in vitro Proliferation verschiedener Ovarial- und Endometriumkarzinomzellinien [PDF]

, 2005
5. Zusammenfassung Ovarial- und Endometriumkarzinome sind in den weiter fortgeschrittenen, rezidivierten oder gar metastasierten Stadien schwierig zu behandeln.
Emons, Günter (Prof. Dr.), Schmidt, Oswald   +1 more
core   +1 more source

Gonadotropin releasing hormone agonists: Expanding vistas

Indian Journal of Endocrinology and Metabolism, 2011
Gonadotropin-releasing hormone (GnRH) agonists are derived from native GnRH by amino acid substitution which yields the agonist resistant to degradation and increases its half-life. The hypogonadotropic hypogonadal state produced by GnRH agonists has been often dubbed as "pseudomenopause" or "medical oophorectomy," which are both misnomers.
openaire   +3 more sources

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

Advanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang   +11 more
wiley   +1 more source

A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep [PDF]

, 2017
Chronic gonadotropin-releasing hormone agonist (GnRHa) administration is used where suppression of hypothalamic-pituitary-gonadal axis activity is beneficial, such as steroid-dependent cancers, early onset gender dysphoria, central precocious puberty and
Bellingham, M., Evans, N.P., Haraldsen, J.R., Hough, D., McLaughlin, M., Robinson, J.E., Solbakk, A.K.   +6 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Profile of Relugolix in the Management of Advanced Hormone-Sensitive Prostate Cancer: Design, Development, and Place in Therapy

Drug Design, Development and Therapy, 2023
Tomoyuki Tatenuma,1,2 Hiroshi Miyamoto1,3 1Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA; 2Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan ...
Tatenuma T, Miyamoto H
doaj  

Uterine Leiomyoma with Massive Lymphoid Infiltrate in a Patient with History of Assisted In-Vitro Fertilization

Türk Patoloji Dergisi, 2020
Uterine leiomyomas are the most common benign tumors of the gynecological tract. Massive lymphocytic infiltration has been reported rarely in uterine leiomyomas and it has been described as a pathogenetic correlation with gonadotropin-releasing hormone ...
Monia DI PRETE, Matteo COLLAMARINI, Claudio COLLAMARINI, Francesco SESTI, Alessandro MAURIELLO, Giampiero PALMIERI   +5 more
doaj   +1 more source

Sellar collision tumor involving pituitary gonadotroph adenoma and chondroma: a potential clinical diagnosis [PDF]

, 2018
We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively
Christ, Emanuel, Giger, Olivier, Kuhlen, Dominique, Sahli, Rahel, Vajtai, Istvan   +4 more
core  

Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways [PDF]

, 2016
Glucagon-like peptide-1 (GLP-1), a metabolic signal molecule, regulates reproduction, although, the involved molecular mechanisms have not been elucidated, yet.
Csaba Fekete, Csaba Vastagh, Erik Hrabovszky, Erzsébet Farkas, Flóra Bálint, Imre Farkas, Katalin Skrapits, Zsolt Liposits   +7 more
core   +1 more source

Medical Management of Problematic Sexual Arousal for People With a Sexual Conviction in England and Wales: Challenges, Learning and Progress

Criminal Behaviour and Mental Health, EarlyView.
ABSTRACT Background In England and Wales, the primary treatments for individuals convicted of sexual offences are psychological. However, medication to manage problematic sexual arousal (MMPSA) is gaining importance as an alternative. This article reviews the current evidence surrounding the MMPSA approach.
Belinda Winder, D. Grubin, M. Underwood, Z. Antoniadis, M. Carvalheiro, E. Marshall, C. Norman, R. Bourne, A. Kaul   +8 more
wiley   +1 more source