Results 201 to 210 of about 129,538 (260)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Observations on Therapeutic Effect of Mixed Injection of Pregnant Mare Serum and Chorionic Gonadotropin on Ovarian Hypofunction in Dairy Cows

, 1959
K Murayama, Takeo SHIGEMATSU, Noboru KOMAGOME   +2 more
openalex   +2 more sources

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, EarlyView.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

Additional file 7: of Effect of exogenous gonadotropin on the transcriptome of human granulosa cells and follicular fluid hormone profiles

, 2019
Cuiling Lu, Zhiqiang Yan, Xueling Song, Yang-Ying Xu, Xiaoying Zheng, Rong Li, Ping Liu, Huai-Liang Feng, Jie Qiao   +8 more
openalex   +1 more source

Dosage of exogenous gonadotropins is not associated with blastocyst aneuploidy or live-birth rates in PGS cycles in Chinese women [PDF]

, 2018
Qianqian Wu, Hongchang Li, Yueting Zhu, Wenjie Jiang, Juanjuan Lu, Daimin Wei, Junhao Yan, Zi‐Jiang Chen   +7 more
openalex   +1 more source

Puberty‐Promoting Treatment and Psychosocial Well‐Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial

Clinical Endocrinology, EarlyView.
ABSTRACT Objective In boys, constitutional delay of growth and puberty (CDGP) has been associated with diverse negative psychosocial effects. Albeit alleviating distress is one of the main reasons for inducing pubertal development, the impact of puberty‐promoting treatment on psychosocial wellbeing is under‐researched.
Laura Kariola, Tero Varimo, Mitja Lääperi, Hanna Huopio, Sirpa Tenhola, Raimo Voutilainen, Jorma Toppari, Silja Kosola, Päivi J. Miettinen, Olli Raitakari, Marko Elovainio, Taneli Raivio, Matti Hero   +12 more
wiley   +1 more source

Urinary Gonadotropins as Markers of Puberty in Girls and Boys During Late Childhood and Adolescence: Evidence From the SCAMP Cohort

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Urinary gonadotropins measurement is a noninvasive method for evaluation of pubertal development and may have utility in population studies. Objectives To investigate the utility of urinary gonadotropins as a noninvasive biomarker of puberty in boys and girls.
Alexander Spiers, Supitcha Patjamontri, Rachel B. Smith, Chen Shen, Mireille B. Toledano, S. Faisal Ahmed   +5 more
wiley   +1 more source

Effects of intramuscular injections of vitamin E-selenium and a gonadotropin releasing hormone analogue (GnRHa) on reproductive performance and blood metabolites of post-molt male broiler breeders

, 2016
Ahmad Hezarjaribi, Vahid Rezaeipour, Rohullah Abdollahpour   +2 more
openalex   +1 more source

Mixed Gonadal Dysgenesis: A Comprehensive Review of Clinical Spectrum, Diagnostic Strategies, and Management Approaches

Clinical Endocrinology, EarlyView.
ABSTRACT Background Mixed gonadal dysgenesis (MGD) is a rare form of differences in sex development (DSD) typically associated with 45,X/46,XY mosaicism. The phenotypic presentation of MGD varies from atypical genitalia to typical male or female appearances often associated with Turner stigmata.
Dinesh Giri, Sushil Yewale, Hannah Hickingbotham, Cara Williams, Mohamed Shalaby, Julie Alderson, Julie Park   +6 more
wiley   +1 more source