Results 271 to 280 of about 221,331 (308)

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

Obesity, Volume 34, Issue 2, Page 499-511, February 2026.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli, Chrisitne Poitou, Mathieu Georget, Françoise Bertin, Ahlam Azar‐Kolakez, Claire Carette, Pauline Faucher, Blandine Gatta‐Cherifi, Julie Gonneau‐Lejeune, Agnès Linglart, Karine Clément, Johanne Le Beyec‐Le Bihan, Béatrice Dubern   +12 more
wiley   +1 more source

Clinical and genetic characteristics of boys with congenital hypogonadotropic hypogonadism: a single-center experience. [PDF]

BMC Pediatr
Fu D, Chen Y, Wu X, Wang H, Gao J, Wei H.   +5 more
europepmc   +1 more source

Factors Associated With Male Breast Cancer Incidence Among Prostate Cancer Survivors: Real World Evidence From Veterans Affairs National Prostate Cancer Data Core

The Prostate, Volume 86, Issue 2, Page 227-235, February 2026.
ABSTRACT Background While male breast cancer incidence is rare, veteran status is found to be associated with increased risk, for incidence, a higher prevalence of male breast cancer patients was observed among male veteran prostate cancer survivors.
Erum Z. Whyne, Sung‐Hee Choi, Nisha Unni, Shifa Kanjwal, Jonathan E. Dowell, Haekyung Jeon‐Slaughter   +5 more
wiley   +1 more source

Options for Final Oocyte Maturation Trigger: Can the Ovarian Response Prediction Index (ORPI) Guide the Optimal Choice? [PDF]

JBRA Assist Reprod
Franco Junior JG, Petersen CG, Meziara JB, Oliveira JBA.   +3 more
europepmc   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Effect of type 2 diabetes mellitus on sperm quality and outcomes of assisted reproductive techniques in infertile male patients. [PDF]

Front Endocrinol (Lausanne)
Wang R, Zhang Y, Li H, Liu W, Xu L, Lu M.   +5 more
europepmc   +1 more source

Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2‐Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging

Aging Cell, Volume 25, Issue 2, February 2026.
A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Sainan Zhang, Jiahui Qi, Chuanming Liu, Huidan Zhang, Bichun Guo, Die Wu, Yicen Liu, Xin Zhen, Yang Zhang, Nannan Kang, Jidong Zhou, Guijun Yan, Chaojun Li, Lijun Ding, Haixiang Sun   +14 more
wiley   +1 more source

Recurrent Beta-Human Chorionic Gonadotropin (β-hCG) Elevation and Suspicion of Gestational Trophoblastic Neoplasia Following a Complete Hydatidiform Mole in a 17-Year-Old Female Patient: A Case Report. [PDF]

Cureus
Mujkanovic-Dzino A, Muracevic-Begovic B, Iriskic R.   +2 more
europepmc   +1 more source

Gonadal function in males with WFS1 spectrum disorder (Wolfram syndrome)—A European cohort perspective

Andrology, Volume 14, Issue 2, Page 398-410, February 2026.
Abstract Background WFS1 spectrum disorder, also known as Wolfram syndrome (WS) is an ultra‐rare (<1:500,000; ORPHA: 3463) monogenic (OMIM #222300) progressive neuroendocrine and neurodegenerative disorder, characterised by early‐onset insulin‐dependent diabetes, optic atrophy, central diabetes insipidus and sensi‐neuronal deafness.
Julia Rohayem, Olivia Cunningham, Denise Williams, Joachim Wistuba, Liam McCarthy, Timothy G. Barrett, Renuka P. Dias   +6 more
wiley   +1 more source