Results 61 to 70 of about 73,970 (344)

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre‐ and Post‐Implantation Epigenetic Barriers

Advanced Science, EarlyView.
Mammalian cloning via SCNT is limited by several epigenetic barriers. Kdm4d/Kdm5b overexpression plus TSA treatment overcomes epigenetic barriers during pre‐implantation development, while tetraploid complementation replaces defective extraembryonic lineages to bypass H3K27me3 imprinting loss to overcome epigenetic barriers in post‐implantation ...
Yamei Li, Shiyu Sun, Yuting Xu, Jixiang Zhang, Yi Du, Yaxin Cao, Zhaodi Liao, Yali Xie, Xinyan Bian, Jiantao Huang, Meijiao Wang, Zhen Liu, Qiang Sun, Falong Lu   +13 more
wiley   +1 more source

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

Advanced Science, EarlyView.
Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge, Yuqing Gao, Feifei Du, Chiyuan Ma, Tianxia Xiao, Yali Yang, Xiaohua Lei, Jian V. Zhang   +7 more
wiley   +1 more source

Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?

Indian Journal of Endocrinology and Metabolism, 2013
Objective: We evaluated the effect of packed red cell transfusion (PCTx) on serum concentrations of gonadotropins luteinizing hormone and follicle-stimulating hormone (LH and FSH) and testosterone (T) levels and measured sperm parameters in young adults ...
Ashraf T Soliman, Mohamed Yasin, Ahmed El-Awwa, Mohamed O Abdelrahman, Vincenzo De Sanctis   +4 more
doaj   +1 more source

Gonadotropin Gene Modulation by Steroids and Gonadotropin-Releasing Hormone1 [PDF]

Biology of Reproduction, 1996
Physiological gonadotropin levels are modulated by complex interrelationships between the sex steroids and the hypothalamic GnRH pulse generator, and the steroids and GnRH individually regulate gonadotropin subunit (alpha, LH beta, FSH beta) gene expression.
openaire   +3 more sources

Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients

Brazilian Journal of Medical and Biological Research, 1999
Secretion of the a-subunit of pituitary glycoprotein hormones usually follows the secretion of intact gonadotropins and is increased in gonadal failure and decreased in isolated gonadotropin deficiency.
Oliveira M.C., Pizarro C.B., Cassal A., Cremonese R., Vieira J.G.H.   +4 more
doaj  

Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies [PDF]

, 2008
Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis.
Christopher I. Amos, Gang Peng, H1oicheong Siu, Jinying Zhao, John D. Reveille, Li Jin, Li Luo, Momiao Xiong, Pengfei Hu, Shengjun Hong, Xiaodong Zhou, Yun Zhu   +11 more
core   +1 more source

The Value of Comparative Animal Research : Krogh’s Principle Facilitates Scientific Discoveries [PDF]

, 2017
There are no conflicts of interest to declare. This paper developed from the 2016 Early Career Impact Award from the Federation of Associations in Behavioral & Brain Sciences to TJS. TJS has received funding from The Leverhulme Trust.
Alward, Beau A., Ebling, Francis J. P., Fernald, Russell D., Kelly, Aubrey, Ophir, Alexander G., Stevenson, Tyler J   +5 more
core   +2 more sources

A Splice‐Region Variant Causes an Atypical Presentation of GNAS Inactivation Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in GNAS can cause a wide range of diseases including pseudohypoparathyroidism, pseudopseudohypoparathyroidism, McCune‐Albright syndrome, among others. The specific phenotypic features that may be seen are influenced by the variant type and location in the gene, whether it causes loss or gain of function, and whether it is ...
Brandon S. Stone, Swetha Ramadesikan, Regan McGinley, Scott E. Hickey, Leeran B. Dublin‐Ryan, Steven I. Estes, Victoria A. Elliott, Benjamin Karabasz, Jesse M. Hunter, Bimal P. Chaudhari, Richard K. Wilson, Daniel C. Koboldt   +11 more
wiley   +1 more source

Transgenic Drosophila Expressing Active Human LH Receptor in the Gonads Exhibit a Decreased Fecundity: Towards a Platform to Identify New Orally Active Modulators of Gonadotropin Receptor Activity

Pharmaceuticals
Background/Objectives: The gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and their receptors are major regulators of reproduction in mammals and are absent in insects.
Amir Mahamid, David Ben-Menahem
doaj   +1 more source

Gonadotropin-Inhibitory Hormone (GnIH):Discovery, Progress and Perspecitive

The Journal of Poultry Science, 2006
Probing undiscovered neuropeptides that play important roles in the regulation of pituitary function is essential for the progress of avian endocrinology and neuroendocrinology. Neuropeptide control of gonadotropin secretion at the level of the anterior
Kazuyoshi Tsutsui
doaj   +1 more source