Results 11 to 20 of about 30,616 (272)

Zoliflodacin versus ceftriaxone plus azithromycin for treatment of uncomplicated urogenital gonorrhoea: an international, randomised, controlled, open-label, phase 3, non-inferiority clinical trial

Lancet, The
Luckey A, Balasegaram M, Barbee LA, Batteiger TA, Broadhurst H, Cohen SE, Delany-Moretlwe S, de Vries HJC, Dionne JA, Gill K, Kenyon C, Kittiyaowamarn R, Lewis D, Mueller JP, Naicker V, O'Brien S, O'Donnell JP, Phanuphak N, Spooner E, Srinivasan S, Taylor SN, Unemo M, Zwane Z, Hook EW, Zoliflodacin Phase 3 Study Group.   +24 more
exaly   +2 more sources

Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study.

Lancet. Infectious Diseases (Print), 2022
BACKGROUND Declining antimicrobial susceptibility to current gonorrhoea antibiotic treatment and inadequate treatment options have raised the possibility of untreatable gonorrhoea. New prevention approaches, such as vaccination, are needed.
W. Abara, K. Bernstein, Felicia M. T. Lewis, J. Schillinger, K. Feemster, P. Pathela, S. Hariri, A. Islam, M. Eberhart, I. Cheng, Alexandra Ternier, J. Slutsker, Sarah A Mbaeyi, R. Madera, R. Kirkcaldy   +14 more
semanticscholar   +1 more source

Treatment of bacterial sexually transmitted infections in Europe: gonorrhoea, Mycoplasma genitalium, and syphilis

The Lancet Regional Health - Europe, 2023
Summary This review explores the therapeutic challenges of sexually transmitted infections (STI) in Europe, which include increasing antimicrobial resistance and limited progress in drug discovery. We primarily focus on gonorrhoea, Mycoplasma genitalium,
O. Mitjà, Clara Suñer, L. Giacani, M. Vall-Mayans, G. Tiplica, Jonathan D C Ross, C. Bradshaw   +6 more
semanticscholar   +1 more source

Evaluating the effectiveness of the 4CMenB vaccine against invasive meningococcal disease and gonorrhoea in an infant, child and adolescent program: protocol

Human Vaccines & Immunotherapeutics, 2021
Invasive meningococcal disease causes significant morbidity and mortality worldwide, with serogroup B being one of the predominant serogroups in Australia for many years.
Helen S. Marshall, Prabha H. Andraweera, Bing Wang, Mark McMillan, Ann P. Koehler, Noel Lally, Sara Almond, Emma Denehy, Michele A’Houre, Lynne C. Giles, Louise Flood   +10 more
doaj   +1 more source

Gepotidacin: a novel, oral, 'first-in-class' triazaacenaphthylene antibiotic for the treatment of uncomplicated urinary tract infections and urogenital gonorrhoea.

Journal of Antimicrobial Chemotherapy, 2023
The ongoing spread of antimicrobial resistance has made the treatment of uncomplicated urinary tract infections (UTIs) and urogenital gonorrhoea increasingly difficult. New oral treatment options are urgently needed.
Richard Watkins, D. Thapaliya, T. Lemonovich, R. Bonomo   +3 more
semanticscholar   +1 more source

Contact tracing for sexually transmitted infections in Aotearoa New Zealand: a review of clinician-notified gonorrhoea and syphilis data [PDF]

Journal of Primary Health Care, 2023
Introduction The sexually transmitted infections (STIs) gonorrhoea and syphilis became notifiable in Aotearoa New Zealand in 2017, requiring diagnosing clinicians to complete an anonymous case report form detailing behavioural, clinical and management ...
Michael G. Baker, Amanda Kvalsvig, Sally B. Rose, Catriona Murray   +3 more
doaj  

Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2022
We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia.
S. Pleininger, A. Indra, D. Golparian, F. Heger, S. Schindler, S. Jacobsson, S. Heidler, M. Unemo   +7 more
semanticscholar   +1 more source

Gonorrhoea Diagnostic and Treatment Uncertainties: Risk Factors for Culture Negative Confirmation after Positive Nucleic Acid Amplification Tests. [PDF]

PLoS ONE, 2016
Gonorrhoea incidence has increased substantially in Stockholm during the past years. These increases have coincided with changes in testing practice from solely culture-based to nucleic acid amplification tests (NAAT).
Rebecka Vyth, Amy Leval, Björn Eriksson, Eva-Lena Ericson, Lena Marions, Maria-Pia Hergens   +5 more
doaj   +1 more source

Public health impact and cost-effectiveness of gonorrhoea vaccination: an integrated transmission-dynamic health-economic modelling analysis

Lancet. Infectious Diseases (Print), 2022
Summary Background Gonorrhoea is a rapidly growing public health threat, with rising incidence and increasing drug resistance. Evidence that the MeNZB and four-component serogroup B meningococcal (4CMenB) vaccines, designed against Neisseria meningitidis,
L. Whittles, X. Didelot, P. White
semanticscholar   +1 more source

The potential public health impact of adolescent 4CMenB vaccination on Neisseria gonorrhoeae infection in England: a modelling study

BMC Public Health, 2023
Introduction Diagnoses of gonorrhoea in England rose by 26% between 2018 and 2019. Recent evidence that a vaccine against meningococcal B disease currently offered to infants in the UK (4CMenB) could additionally protect (with 31% efficacy) against ...
Katharine J. Looker, Ross Booton, Najida Begum, Ekkehard Beck, Jing Shen, Katherine M. E. Turner, Hannah Christensen   +6 more
doaj   +1 more source