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CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride [PDF]

Clinical and Translational Science, 2022
Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease.
Diana María Campodónico +12 more
doaj +3 more sources

Implementation of extreme collaboration methodology in a Capstone project course [PDF]

Scientific Reports
Civil engineers’ training requires developing competencies and skills that allow them to face the challenges of professional practice. In this context, this study explores the implementation of the Extreme Collaboration (XC) methodology in an integrative
Eric Forcael +5 more
doaj +3 more sources

Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome [PDF]

Frontiers in Medicine, 2023
IntroductionLong-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, the ...
Sergio Sanhueza +55 more
doaj +3 more sources

Prepectoral and Retropectoral Breast-implant–Associated Anaplastic Large-cell Lymphoma [PDF]

Plastic and Reconstructive Surgery, Global Open
Summary:. Breast-implant–associated anaplastic large cell lymphoma (BIA-ALCL) is a non-Hodgkin lymphoma that arises in the space between the surface of a breast implant and the fibrous capsule that grows around the implant. Since its first description 20
Gonzalo Ziegler-Rodriguez, MD, FACS +10 more
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Comprehensive methodology for evaluating the immobility responses in laboratory animals [PDF]

MethodsX
From an evolutionary perspective, all organisms have two purposes: self-preservation and reproduction, in which immobility responses (IR) are implicated, these are ancestral survival strategies used to avoid serious injury or death.
M. Alejandra Estrada-Silva +11 more
doaj +3 more sources

Shear bond strength evaluation of metallic brackets bonded to a CAD/CAM PMMA material compared to traditional prosthetic temporary materials: an in vitro study [PDF]

Dental Press Journal of Orthodontics, 2020
Introduction: Orthodontic treatment for adults is currently increasing, and therefore the need to bond brackets to restorations and temporary crowns. The use of CAD/CAM PMMA provisional restorations for orthodontic purposes have not yet been described ...
Gonzalo Andrés Garcés +3 more
doaj +2 more sources

ATLAS2030 Pediatric Gait Exoskeleton: Changes on Range of Motion, Strength and Spasticity in Children With Cerebral Palsy. A Case Series Study [PDF]

Frontiers in Pediatrics, 2021
Background: Cerebral Palsy (CP), the most common motor disability in childhood, affects individual's motor skills, movement and posture. This results in limited activity and a low social participation. The ATLAS2030 exoskeleton is a pediatric device that
Elena Delgado +14 more
doaj +2 more sources

Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study [PDF]

BMJ Open, 2022
Introduction The growing worldwide prevalence of Alzheimer’s disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly recognised as a risk factor and ...
Henrik Zetterberg +23 more
doaj +2 more sources

Pharmacogenetic Biomarkers of Ibrutinib Response and Toxicity in Chronic Lymphocytic Leukemia: Insights from an Observational Study [PDF]

Pharmaceuticals
Background/Objectives: Ibrutinib is a selective Bruton’s tyrosine kinase inhibitor approved for the treatment of chronic lymphocytic leukemia (CLL). This drug exhibits significant variability in response and toxicity profile, possibly due to genetic ...
Noelia Pérez-Gómez +21 more
doaj +2 more sources

Domains for inclusion in a novel Treatment Response Measure for Systemic Lupus Erythematosus (TRM-SLE): results of a modified Delphi study [PDF]

Lupus Science and Medicine
Objectives To achieve consensus on domains of active disease for inclusion in a novel outcome measure for SLE randomised controlled trials (RCTs), the Treatment Response Measure for SLE (TRM-SLE).Methods Domains nominated by TRM-SLE Taskforce members ...
+177 more
doaj +2 more sources

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