Results 141 to 150 of about 4,403,980 (269)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A descriptive, retrospective analysis of the quality of spontaneous adverse event reporting to the Côte d'Ivoire Pharmaceutical and Regulatory Authority and its impact on the causality assessment. [PDF]

Ther Adv Drug Saf
Kamagaté M, Jusot V, Mory D, Barry A, Adou F, Kirabo M, Perger T, Guerra Mendoza Y.   +7 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Development of Data-Driven Models for Just-in-Time Digital Self-Management Advice to Improve Physical Functioning in Hip and Knee Osteoarthritis: Protocol for the e-cOAch Cross-Over Study. [PDF]

JMIR Res Protoc
Groen F, de Rooij M, Kloek CJJ, Veenhof C, Klein MCA, Al-Janabi A, van Haeringen ES, Ronteltap A, Paans-Cijs B, van Dongen B, Ginsel DE, Barten DA, Hoogeboom TJ, Pisters MF.   +13 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Knowledge, attitudes and practices towards uncomplicated malaria management and LLIN use in Kumba and Muyuka, Cameroon: a cross-sectional study. [PDF]

BMJ Public Health
Tongwa DZ, Ndim MCF, Mbiziwoh TP, Chi YM, Tatah CA, Ngome FN, Kofon JP, Elad PCK, Tsobgni SPK, Mbonigaba E, Nyanjoh EM, Tassang AN, Cho FN.   +12 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Predictive Value of Combined Serum NOX4, Gal-13, and Cyclophilin A for Prognosis in Severe Pneumonia. [PDF]

Int J Gen Med
Liu Q, Meng H, Sun H.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Good Life with Dementia approach: A realist-informed qualitative study of a peer-tutored course, co-produced with and for people living with dementia. [PDF]

PLoS One
Gridley K, Wilberforce M, Mann R, Tucker L, Casey B, Clarke C, Creavin S, Donaldson I, Gordon H, Murphy D, Pearson M, Rauf MA, Birks Y.   +12 more
europepmc   +1 more source