Results 141 to 150 of about 8,572,674 (314)

Report of the Council of the University of the Cape of Good Hope eighteen eighty one

open access: yes, 2015
Report on the proceedings of the University of the Cape of Good Hope for 1881.Official 1881 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.

core  

Only one world: men in the cave, release and ascension

open access: yesCivilizar, 2014
In this paper the author approaches the complex relationship between the three similes employed by Plato en The Republic, in Books VI and VII. The proposal is that the simile of the cave can be understood as a “phenomenological” movement, that is, a ...
César Delgado Lombana
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Report of the Council of the University of the Cape of Good Hope eighteen ninety two

open access: yes, 2015
Report of the proceedings of the University of the Cape of Good Hope during 1892.Official 1892 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.

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Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Report of the Council of the University of the Cape of Good Hope eighteen eighty eight

open access: yes, 2015
Report of the proceedings of the University of the Cape of Good Hope during 1888.Official 1888 Report of the Council of the University of the Cape or Good Hope to the Cape Colonial Parliament.

core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Report of the Council of the University of the Cape of Good Hope eighteen eighty three

open access: yes, 2015
Report of the proceedings of the University of the Cape of Good Hope during 1883.Official 1883 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.

core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Report of the Council of the University of the Cape of Good Hope eighteen seventy nine

open access: yes, 2015
Report on the proceedings of the University of the Cape of Good Hope for 1879.Official 1879 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.

core  

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