Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Assessing governance structures for climate-resilient and sustainable health systems: development of the PHONIC framework. [PDF]
Geffert K +8 more
europepmc +1 more source
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Water quality dynamics in urban river of the semiarid region under anthropogenic pressure: a spatiotemporal analysis in the stretch of the municipality of Mossoró (Brazil). [PDF]
da Silva ALS +10 more
europepmc +1 more source
The Good & Reese Co.'s blue book : autumn 1929 : 83rd semi-annual wholesale price list /
null null, John M. Good
core +1 more source
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Poverty and health - does parenthood matter? Trends in income inequality in self-rated health among parents and non-parents in Germany from 2009 to 2024. [PDF]
Rattay P +4 more
europepmc +1 more source
Good Housekeeping's Book of Good Meals, How to Prepare and Serve Them
Good Housekeeping Institute
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source

