Results 61 to 70 of about 1,072,193 (286)

Dying, death and bereavement: a qualitative study of the views of carers of people with heart failure in the UK [PDF]

, 2009
BACKGROUND: This paper explores carers' views of dying, death and bereavement for family members who had recently died with heart failure adding to a growing literature on end of life experiences for people with conditions other than cancer ...
Seamark David, Small Neil, Gott, M., Sarah Barnes, Gott, Merryn, Merryn Gott, Sheila Payne, Gariballa Salah, Gariballa, S., Salah Gariballa, Parker Chris, Barnes, Sarah, Parker, C., David Seamark, Small, Neil, Gott Merryn, Small, N., Seamark, David, Barnes, S., Chris Parker, Payne, Sheila, Seamark, D., Payne, S., Neil Small, Parker, Chris, Barnes Sarah, Gariballa, Salah, Payne Sheila, Neil Small   +28 more
core   +1 more source

In search of a good death: What is a good death?

BMJ, 2003
EDITOR—Ellershaw and Ward describe how access to good palliative care should be available to all patients who are dying.1 We agree that equity of access is crucially important but disagree with the implied definition of what a good death is. The authors imply that a …
June Jones, Derek Willis
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Investigation of Opinions of Nurses Working in Surgical Intensive Care Units about the Participation of Family Members in the Care of Patients during the Dying Process: A Cross-sectional Design

Türk Yoğun Bakim Derneği Dergisi
Objective: This study was conducted to determine the opinions of nurses working in surgical intensive care units (S-ICU) about the participation of family members (FM) in the care of patients during the dying process.
Aynur Koyuncu, Yasemin Eren, Ayla Yava
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Dying of cancer : is it the process or the place that contributes to a good death?

, 2012
Includes abstract.Includes bibliographical references.This Quantitative Study undertook to investigate what family members or caregivers of deceased patients from a private oncology unit in Cape Town experienced during the last week of that patient’s ...
Manicom, Clare Louise
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source