Results 241 to 250 of about 1,702,112 (292)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Exploring district nurses' experiences with digital encounters in primary healthcare: a qualitative pilot study. [PDF]

BMC Prim Care
Larsson M, Friberger L, Götvall J, Eriksson I.   +3 more
europepmc   +1 more source

No mention of animal welfare in the United Nations' sustainable development goals? But this may be a good thing! [PDF]

Anim Welf
Bull J, Nielsen BL, Silvera A, Tunon H, Keeling LJ.   +4 more
europepmc   +1 more source

Towards Sustainable Good Health and Well-being

openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Associations between community-based aged care services and subjective well-being among older adults in China: the mediating roles of self-rated and mental health. [PDF]

PLoS One
Wang Y, Bai X, Zhao H.
europepmc   +1 more source

'We need to be supported so that we are able to also provide better care' Well-being and self-care needs among health workers providing HIV care to children and adolescents in Africa: Qualitative findings from 12 high HIV-prevalence African countries. [PDF]

PLoS One
Citron C, Gittings L, Oberwasserlechner M, Ronan A, Hatane L.   +4 more
europepmc   +1 more source

Psychosocial correlates of well-being among retired academics at Ghanaian Universities. [PDF]

Health Psychol Behav Med
Owusu-Ansah FE, Opoku D, Tangonyire RC, Adzovie RH, Afriyie Amponsah A, Afriyie Addae A.   +5 more
europepmc   +1 more source

Predictive factors of Black American emerging adults' psychological flourishing: a random forest analysis. [PDF]

Sci Rep
Kebbeh N, Jelsma E.
europepmc   +1 more source

Continuous glucose monitoring, diabetes distress, and well-being in adults with type 1 diabetes: findings from a National Survey in Lithuania. [PDF]

Front Clin Diabetes Healthc
Šuminienė J, Stukas R, Gaigalaite V, Kriaučiūnienė D, Istomina N.   +4 more
europepmc   +1 more source