Results 161 to 170 of about 2,175,426 (304)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Forest landscape mosaics: disturbance, restoration and management at times of global change : [international conference], 11-14 August 2014 Tartu, Estonia : book of abstracts

, 2014
KonverentsikogumikThe nature which surrounds us plays a central role in our existence. This is difficult to comprehend, as usually we place ourselves at the center of human existence.
Estonian University of Life Sciences
core  

Implementing good life with OsteoArthritis from Denmark (GLA:D®) in public outpatient settings in Tasmania, Australia. [PDF]

Osteoarthr Cartil Open
Alamneh YM, Sutton L, Barton C, Balogun S, Lawler K, Djekanovic M, O'Brien LJ, McDonald HM, Youngblutt T, Hyland P, Harvie P, Peterson GM, Collins N, de Graaff B, Van Dam P, Jones G, Aitken D.   +16 more
europepmc   +1 more source

Values of Australian Meat Consumers Related to Sheep and Beef Cattle Welfare: What Makes a Good Life and a Good Death? [PDF]

Food Ethics, 2023
Buddle EA, Bray HJ, Ankeny RA.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Adaptation of the Good Spirit, Good Life quality of life tool for remote Indigenous Australians. [PDF]

Qual Life Res
Gilchrist L, Flicker L, Bessarab D, Malay R, Yambo L, Sagigi B, Wapau C, Russell S, Quigley R, Rivers C, Hyde Z, Chaney E, Strivens E, White C, Smith K.   +14 more
europepmc   +1 more source

What does a "good life" mean for people living with dementia? A protocol for a think-aloud study informing the value of care. [PDF]

Front Aging Neurosci, 2022
Kinchin I, Leroi I, Kennelly SP, Kochovska S, Brady C, Fitzhenry D, McHale C, Kinghorn P, Coast J.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Does the good life feel good? The role of positive emotion in competing conceptions of the good life. [PDF]

Front Psychol
Novak L, Kiknadze N.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source