Results 81 to 90 of about 2,175,426 (304)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Acta AcademicaIn one of the major contributions to current Critical Theory in the 21st century, Hartmut Rosa employs the notion of resonant subject-world-relationships to critically analyse structural features of modern societies that systematically undermine ...
Ole Höffken
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Practising the Good Life Lifestyle Migration in Practices
, 2015 This edited collection adds to the growing body of research on lifestyle migration with empirically grounded explorations focusing on a wide range of practices involved in living 'the good life'. The volume brings together a variety of socio-geographical
David, Inês +2 more
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Successful ageing in an area of deprivation: Part 1—A qualitative exploration of the role of life experiences in good health in old age [PDF]
, 2007 Objectives: To determine the life histories and current circumstances of healthy and unhealthy older people who share an ecology marked by relative deprivation and generally poor health.
Cullen, B. +5 more
core +1 more source
El educador social. Ética y práctica profesional.
Pedagogía Social: Revista Interuniversitaria, 2012 En una sociedad caracterizada por la incertidumbre y la precariedad a los educadores sociales no les basta recurrir a los métodos y técnicas propios de la profesión.
Leonor Ronda Ortín
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Conference Reimagined. Postcards, Letters, and Camping Together in Undressed Places
Digithum, 2019 In this paper, five authors account for the rethinking of a conference as a series of postcards, letters, rules and silent moments so that traditional hierarchies of knowledge could be overturned or, at least, sidelined.
Soile Veijola +4 more
doaj