FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Report of the Council of the University of the Cape of Good Hope eighteen ninety nine
, 2015 Report of the proceedings of the University of the cape of Good Hope during 1899.Official 1906 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.
core
Considering people living with dementia when designing interfaces [PDF]
, 2014 Dementia is an escalating problem which is estimated to affect 35.6 million people worldwide. In an environment which is becoming increasingly dependent on technology, the interaction needs of people living with dementia is being ignored by interface ...
Good, Alice +3 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Report of the Council of the University of the Cape of Good Hope eighteen ninety seven
, 2015 Report of the proceedings of the University of the Cape of Good Hope during 1897.Official 1897 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Prolegómenos al vivir bien-buen vivir: una evaluación normativa y práctica
Revista Finanzas y Política Económica, 2014 Este trabajo examina el concepto de vivir bien-buen vivir ponderando sus contribuciones y limitaciones. Esta cosmovisión tiene un horizonte normativo más ambicioso que el paradigma del desarrollo, pues apuesta por una concepción de la pobreza y la ...
Edwin Cruz Rodríguez
doaj
City marketing: key dimensions of a good living city
Revista Produção e Desenvolvimento, 2015 This article aims to present the results of exploratory research focused on identifying factors that people prioritize when choosing a city of good living.
Simone Beatriz Nunes Ceretta +1 more
doaj +1 more source
From the Good Life to Good Living: A Longitudinal Study Investigating the Relationship Between Good-Life Coherence and Motivation, Goal Progress and Subjective Well-Being. [PDF]
J Happiness Stud, 2022 Thomas B +3 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source