Results 71 to 80 of about 858,465 (296)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Barataria, 2015 This article explains the birth, evolution and subsequent project management of a juvenile intervention in the Northern of the city of Alicante, born in 2007 and remains in effect within a specific Municipal Comprehensive Plan.
Virgilio Francisco Candela Sevila
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
An alternative way to model merit good arguments [PDF]
Besley (1988) uses a scaling approach to model merit good arguments in commodity tax policy. In this paper, I question this approach on the grounds that it produces 'wrong' recommendations--taxation (subsidisation) of merit (demerit) goods--whenever the ...
Fred Schroyen
core
The Good Life: visualizing the complexity of supported living for people with disability
This paper outlines the development of an interactive visualization tool, ‘A Good Life,’ which emerged out of a collaborative project between design researchers and practitioners from the University of Technology Sydney and Northcott, an Australian ...
Hibberd, G +2 more
core +1 more source
Nuevo mundo - Mundos Nuevos, 2019 In this work I am interested in reflecting on the group called the Movement of Indigenous Women for Good Living in Argentina that, since 2015, has been generating different actions in the public arena, denouncing various conflicts that affect indigenous ...
Carolina Álvarez Ávila
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Living a good life?: Considering technology and pro-social behaviour
HTS Teologiese Studies/Theological Studies, 2019 This article explores the notions of a good life as understood in religion and psychology. The markers of altruism and empathy are identified. The effect the use of social media has on brain chemistry is then explored and used in trying to answer the ...
Wessel Bentley
doaj +1 more source
Ethics and Information TechnologyAbstract The paper develops a conception of the good life within a digitalized society. Martha Nussbaum’s capability theory offers an adequate normative framework for that purpose as it systematically integrates the analysis of flourishing human lives with a normative theory of justice.
openaire +1 more source