Results 141 to 150 of about 13,875,312 (245)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Australia at war, field sports, ca. 1918 [picture] /
, 1918 Title devised by cataloguer based on information from inscription.; Part of the collection: A collection of lithographs made from drawings by Will Dyson while acting as a war artist with the Australian Imperial Forces; Inscriptions: "No.
Dyson, Will, 1880-1938.
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Australians at war : back at Buire, December 1916 [picture] /
, 1916 Title from accession sheet.; Part of the collection: A collection of lithographs made from drawings by Will Dyson while acting as a war artist with the Australian Imperial Forces; Inscriptions: Signed by the artist in pencil, lower right; "468/47"--In ...
Dyson, Will, 1880-1938.
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Commentary: It looks good, but will it last?Central Message
JTCVS Open, 2020 Rachel Eikelboom, MD +1 more
doaj +1 more source
Murphy, Will. The Wren Song, sung by Will Murphy, Colliers
, 2009 Colliers resident Will Murphy sings the wren songThe wren is just one of several Christmastime house-visiting traditions that continue in Newfoundland and Labrador. Typically, children and/or adults will visit homes within their community carrying around
Jarvis, Dale;
core