Results 91 to 100 of about 349,134 (285)

Improved kernel estimation of copulas: Weak convergence and goodness-of-fit testing

, 2009
We reconsider the existing kernel estimators for a copula function, as proposed in Gijbels and Mielniczuk [Comm. Statist. Theory Methods 19 (1990) 445--464], Fermanian, Radulovi\v{c} and Wegkamp [Bernoulli 10 (2004) 847--860] and Chen and Huang [Canad. J.
Gijbels, Irène, Omelka, Marek, Veraverbeke, Noël   +2 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Robust correlation coefficient goodness-of-fit test for the Gumbel distribution

Journal of Biostatistics and Epidemiology, 2018
Background & Aim: A single outlier can even have a large disturbing effect on a classical statistical method that is optimal under the classical assumptions.
Abbas Mahdavi
doaj  

Goodness-of-fit testing strategies from indirect observations [PDF]

, 2014
International audienceWe consider in this paper a goodness-of-fit testing problem in a density framework. In particular, we deal with an error-in-variables model where each new incoming observation is gathered with a random independent error.
Loubes, Jean-Michel, Marteau, Clément
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

From Theory to Practice: Exploring the Chi-Squared Goodness-of-Fit Test for Poisson Distributions with Car Parking Data

Journal of Statistical Theory and Applications (JSTA)
This study investigates the impact of design decisions on the outcomes of chi-squared tests when applied to Poisson distributions, using the practical example of arrivals in a parking garage. Through a combination of experiments and simulations, we found
Thomas Müller, Dirk Schweim
doaj   +1 more source

Comparative study of threshold selection methods in the generalised Pareto distribution with application to rainfall datasets

Data Analytics and Applied Mathematics
Extreme rainfall events pose significant challenges for flood risk management and infrastructure planning, necessitating robust statistical tools for accurate risk assessment.
Farabe Khan Alif, Norhaslinda Ali
doaj   +1 more source

Projection-based nonparametric goodness-of-fit testing with functional covariates

, 2012
This paper studies the problem of nonparametric testing for the effect of a random functional covariate on a real-valued error term. The covariate takes values in $L^2[0,1]$, the Hilbert space of the square-integrable real-valued functions on the unit ...
Patilea, Valentin, Sanchez-Sellero, Cesar, Saumard, Matthieu   +2 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source